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Articles Published Processes
4/13/2023 8:14:59 AM | Browse: 197 | Download: 770
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Received |
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2022-12-17 13:37 |
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Peer-Review Started |
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2022-12-17 13:39 |
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To Make the First Decision |
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Return for Revision |
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2023-01-22 21:56 |
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Revised |
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2023-02-01 06:12 |
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Second Decision |
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2023-03-15 03:13 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-03-16 16:51 |
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Articles in Press |
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2023-03-16 16:51 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-04-04 01:52 |
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Publish the Manuscript Online |
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2023-04-13 08:14 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Parasitology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect and mechanism of reactive oxygen species-mediated NOD-like receptor family pyrin domain-containing 3 inflammasome activation in hepatic alveolar echinococcosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cai-Song Chen, Yao-Gang Zhang, Hai-Jiu Wang and Hai-Ning Fan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Major Research and Development Project of “Precision Medicine Research” |
2017YFC0909900 |
| Qinghai Province Science and Technology Department Programme |
2019-SF-131 |
| Qinghai Province Health and Family Planning Commission Programme |
2016-wjzd-04 |
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| Corresponding Author |
Hai-Ning Fan, MD, Doctor, Doctor, Professor, Department of Hepatobiliary and Pancreatic Surgery, Qinghai Province Research Key Laboratory for Echinococcosis, Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Xining 810001, Qinghai Province, China. fanhaining6@yeah.net |
| Key Words |
Hepatic alveolar echinococcosis; Inflammasome; Inflammation; Kupffer cell; NLR family pyrin domain-containing 3 protein; Reactive oxygen species |
| Core Tip |
In recent years, the role of the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in parasitic diseases has attracted widespread attention. However, the role and clinical significance of the NLRP3 inflammasome in Hepatic alveolar echinococcosis (HAE) remain unclear. Herein, we explored the mode of NLRP3 inflammasome activation in the tissues of patients with HAE, a rat model of HAE, rat Kupffer cells, and hepatocytes. Our experiments showed that inhibiting reactive oxygen species (ROS) production reduces NLRP3-caspase-1-IL-1β pathway activation. Decreased IL-1β expression alleviated inflammation and apoptosis rates in hepatocytes in HAE. We conclude that ROS-mediated NLRP3 inflammasome activation was a key factor leading to hepatocyte injury and triggering a cascade of inflammatory reactions. Therefore, ROS production may be a promising target for the treatment of HAE. |
| Publish Date |
2023-04-13 08:14 |
| Citation |
Chen CS, Zhang YG, Wang HJ, Fan HN. Effect and mechanism of reactive oxygen species-mediated NOD-like receptor family pyrin domain-containing 3 inflammasome activation in hepatic alveolar echinococcosis. World J Gastroenterol 2023; 29(14): 2153-2171 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i14/2153.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i14.2153 |
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