Publication Name	World Journal of Stem Cells
Manuscript ID	82769
Country	Lebanon

Received	2022-12-28 10:05
Peer-Review Started	2022-12-28 10:07
To Make the First Decision
Return for Revision	2023-01-31 00:18
Revised	2023-02-14 10:19
Second Decision	2023-04-12 03:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-04-12 08:01
Articles in Press	2023-04-12 08:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-05-17 08:38
Publish the Manuscript Online	2023-05-26 11:17

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Review
Article Title	Tissue-specific cancer stem/progenitor cells: Therapeutic implications
Manuscript Source	Invited Manuscript
All Author List	Amani Yehya, Joe Youssef, Sana Hachem, Jana Ismael and Wassim Abou-Kheir
ORCID	Author(s) ORCID Number Wassim Abou-Kheir http://orcid.org/0000-0001-9719-9324
Funding Agency and Grant Number
Corresponding Author	Wassim Abou-Kheir, MSc, PhD, Associate Professor, Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Bliss Street, Hamra, Beirut 1107-2020, Lebanon. wa12@aub.edu.lb
Key Words	Cancer stem cells; Therapy resistance; Tissue-specific cancer stem cell markers; Patient-derived organoids; Pre-clinical cancer models
Core Tip	Therapeutic approaches targeting cancer stem cell (CSC) markers hold great promise toward developing effective anti-cancer treatment. Tissue-specific CSCs (TSCSCs) possess unique expression profile that allows for their identification, isolation, and targeting. TSCSCs, isolated from patient tumor tissues, were shown to form organ analogs or patient-derived organoids (PDOs) under specific culturing conditions in vitro. These models simulate the original tumor characteristics in a three-dimensional culture dish. As such, PDOs have the potential to be used in patient-specific in vitro drug clinical trials and proof-of-concept studies on CSC-targeted therapies.
Publish Date	2023-05-26 11:17
Citation	Yehya A, Youssef J, Hachem S, Ismael J, Abou-Kheir W. Tissue-specific cancer stem/progenitor cells: Therapeutic implications. World J Stem Cells 2023; 15(5): 323-341
URL	https://www.wjgnet.com/1948-0210/full/v15/i5/323.htm
DOI	https://dx.doi.org/10.4252/wjsc.v15.i5.323

Full Article (PDF)	WJSC-15-323.pdf
Full Article (Word)	WJSC-15-323.docx
Manuscript File	82769_Auto_Edited-JLW.docx
Answering Reviewers	82769-Answering reviewers.pdf
Audio Core Tip	82769-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	82769-Conflict-of-interest statement.pdf
Copyright License Agreement	82769-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	82769-Language certificate.pdf
Peer-review Report	82769-Peer-review(s).pdf
Scientific Misconduct Check	82769-Bing-Li L-2.png
Scientific Editor Work List	82769-Scientific editor work list.pdf
CrossCheck Report	82769-CrossCheck report.pdf
CrossCheck Report	82769-CrossCheck.png