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5/26/2023 11:17:59 AM | Browse: 127 | Download: 201
Publication Name World Journal of Stem Cells
Manuscript ID 82769
Country/Territory Lebanon
Received
2022-12-28 10:05
Peer-Review Started
2022-12-28 10:07
To Make the First Decision
Return for Revision
2023-01-31 00:18
Revised
2023-02-14 10:19
Second Decision
2023-04-12 03:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-04-12 08:01
Articles in Press
2023-04-12 08:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-05-17 08:38
Publish the Manuscript Online
2023-05-26 11:17
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Tissue-specific cancer stem/progenitor cells: Therapeutic implications
Manuscript Source Invited Manuscript
All Author List Amani Yehya, Joe Youssef, Sana Hachem, Jana Ismael and Wassim Abou-Kheir
ORCID
Author(s) ORCID Number
Wassim Abou-Kheir http://orcid.org/0000-0001-9719-9324
Funding Agency and Grant Number
Corresponding Author Wassim Abou-Kheir, MSc, PhD, Associate Professor, Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Bliss Street, Hamra, Beirut 1107-2020, Lebanon. wa12@aub.edu.lb
Key Words Cancer stem cells; Therapy resistance; Tissue-specific cancer stem cell markers; Patient-derived organoids; Pre-clinical cancer models
Core Tip Therapeutic approaches targeting cancer stem cell (CSC) markers hold great promise toward developing effective anti-cancer treatment. Tissue-specific CSCs (TSCSCs) possess unique expression profile that allows for their identification, isolation, and targeting. TSCSCs, isolated from patient tumor tissues, were shown to form organ analogs or patient-derived organoids (PDOs) under specific culturing conditions in vitro. These models simulate the original tumor characteristics in a three-dimensional culture dish. As such, PDOs have the potential to be used in patient-specific in vitro drug clinical trials and proof-of-concept studies on CSC-targeted therapies.
Publish Date 2023-05-26 11:17
Citation Yehya A, Youssef J, Hachem S, Ismael J, Abou-Kheir W. Tissue-specific cancer stem/progenitor cells: Therapeutic implications. World J Stem Cells 2023; 15(5): 323-341
URL https://www.wjgnet.com/1948-0210/full/v15/i5/323.htm
DOI https://dx.doi.org/10.4252/wjsc.v15.i5.323
Full Article (PDF) WJSC-15-323.pdf
Full Article (Word) WJSC-15-323.docx
Manuscript File 82769_Auto_Edited-JLW.docx
Answering Reviewers 82769-Answering reviewers.pdf
Audio Core Tip 82769-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 82769-Conflict-of-interest statement.pdf
Copyright License Agreement 82769-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 82769-Language certificate.pdf
Peer-review Report 82769-Peer-review(s).pdf
Scientific Misconduct Check 82769-Bing-Li L-2.png
Scientific Editor Work List 82769-Scientific editor work list.pdf