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Articles Published Processes
5/26/2023 11:17:59 AM | Browse: 591 | Download: 1292
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Received |
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2022-12-28 10:05 |
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Peer-Review Started |
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2022-12-28 10:07 |
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First Decision by Editorial Office Director |
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2023-01-31 00:18 |
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Return for Revision |
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2023-01-31 00:18 |
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Revised |
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2023-02-14 10:19 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-04-12 03:09 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-04-12 08:01 |
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Articles in Press |
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2023-04-12 08:01 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-05-17 08:38 |
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Publish the Manuscript Online |
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2023-05-26 11:17 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Tissue-specific cancer stem/progenitor cells: Therapeutic implications
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Amani Yehya, Joe Youssef, Sana Hachem, Jana Ismael and Wassim Abou-Kheir |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wassim Abou-Kheir, MSc, PhD, Associate Professor, Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Bliss Street, Hamra, Beirut 1107-2020, Lebanon. wa12@aub.edu.lb |
| Key Words |
Cancer stem cells; Therapy resistance; Tissue-specific cancer stem cell markers; Patient-derived organoids; Pre-clinical cancer models |
| Core Tip |
Therapeutic approaches targeting cancer stem cell (CSC) markers hold great promise toward developing effective anti-cancer treatment. Tissue-specific CSCs (TSCSCs) possess unique expression profile that allows for their identification, isolation, and targeting. TSCSCs, isolated from patient tumor tissues, were shown to form organ analogs or patient-derived organoids (PDOs) under specific culturing conditions in vitro. These models simulate the original tumor characteristics in a three-dimensional culture dish. As such, PDOs have the potential to be used in patient-specific in vitro drug clinical trials and proof-of-concept studies on CSC-targeted therapies. |
| Publish Date |
2023-05-26 11:17 |
| Citation |
Yehya A, Youssef J, Hachem S, Ismael J, Abou-Kheir W. Tissue-specific cancer stem/progenitor cells: Therapeutic implications. World J Stem Cells 2023; 15(5): 323-341 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i5/323.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i5.323 |
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