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Articles Published Processes
6/15/2023 8:52:34 AM | Browse: 173 | Download: 352
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Received |
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2022-12-28 04:45 |
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Peer-Review Started |
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2022-12-28 04:46 |
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To Make the First Decision |
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Return for Revision |
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2023-02-08 01:34 |
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Revised |
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2023-02-10 08:49 |
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Second Decision |
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2023-04-23 03:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-04-24 02:49 |
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Articles in Press |
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2023-04-24 02:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-04-23 00:03 |
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Typeset the Manuscript |
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2023-06-07 01:30 |
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Publish the Manuscript Online |
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2023-06-15 08:52 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Targeting epicardial adipose tissue: A potential therapeutic strategy for heart failure with preserved ejection fraction with type 2 diabetes mellitus
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yu-Jiao Shi, Guo-Ju Dong and Ming Guo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Guo-Ju Dong, MD, PhD, Chief Physician, Department of Cardiovascular Medicine, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, No. 1 Xiyuan Playground, Haidian District, Beijing 100091, China. 13691393589@163.com |
| Key Words |
Epicardial adipose tissue; Heart failure with preserved ejection fraction; Type 2 diabetes mellitus; Inflammation; Anti-hyperglycemic drugs; Sodium-glucose cotransporter-2 inhibitors |
| Core Tip |
Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. Effective interventions are lacking due to the complex pathophysiological underpinnings. Nevertheless, it is essential to provide individualized treatment depending on phenotypic differences. HFpEF with type 2 diabetes mellitus (T2DM) is a specific phenotype of HFpEF, and its emergence and progression are strongly associated with the expansion, inflammation, and hypermetabolic activity of epicardial adipose tissue (EAT). Thus, targeting EAT may be a promising therapeutic strategy for HFpEF with T2DM. Currently, lifestyle management, bariatric surgery, and certain drugs related to anti-cytokines, anti-hyperglycemia, and anti-hyperlipidemia may help to suppress the accumulation of EAT and be beneficial in improving the clinical symptoms and prognosis of HFpEF patients. Accordingly, more standardized randomized controlled studies are required to validate the efficacy of current treatments. It is also essential to thoroughly understand the pathological mechanisms underlying the aberrant expansion of EAT, thus helping to develop new effective therapies. |
| Publish Date |
2023-06-15 08:52 |
| Citation |
Shi YJ, Dong GJ, Guo M. Targeting epicardial adipose tissue: A potential therapeutic strategy for heart failure with preserved ejection fraction with type 2 diabetes mellitus. World J Diabetes 2023; 14(6): 724-740 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i6/724.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i6.724 |
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