Publication Name	World Journal of Clinical Cases
Manuscript ID	82809
Country	India

Received	2022-12-28 04:26
Peer-Review Started	2022-12-28 04:28
To Make the First Decision
Return for Revision	2023-01-30 08:14
Revised	2023-02-13 06:02
Second Decision	2023-04-06 03:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-04-06 08:06
Articles in Press	2023-04-06 08:06
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-04-02 18:36
Typeset the Manuscript	2023-04-25 07:56
Publish the Manuscript Online	2023-05-16 09:24

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Psychiatry
Manuscript Type	Opinion Review
Article Title	Modernising autism spectrum disorder model engineering and treatment via CRISPR-Cas9: A gene reprogramming approach
Manuscript Source	Invited Manuscript
All Author List	Arushi Sandhu, Anil Kumar, Kajal Rawat, Vipasha Gautam, Antika Sharma and Lekha Saha
ORCID	Author(s) ORCID Number Lekha Saha http://orcid.org/0000-0001-5925-7159
Funding Agency and Grant Number
Corresponding Author	Lekha Saha, MBBS, MD, MNAMS, Full Professor, Professor, Department of Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh 0172, Chandigarh, India. lekhasaha@rediffmail.com
Key Words	Autism spectrum disorder; CRISPR-Cas9; Cellular models; Organoids; Animal models; Therapeutic strategies
Core Tip	There are several reviews in the literature explaining the underlying mechanisms contributing to the pathophysiology of autism spectrum disorder by performing several preclinical experiments. Given the significant role of genetics (de novo or inheritable) in the development of autism spectrum disorder, disease specific models should be established for investigating the mechanism involved. Therefore, this review specifically focused on the use of an emerging genomic editing tool, clustered regularly inters-paced palindromic repeats/Cas9, for generating different types of preclinical models as well as new therapeutic options, providing a novel insight into the disease.
Publish Date	2023-05-16 09:24
Citation	Sandhu A, Kumar A, Rawat K, Gautam V, Sharma A, Saha L. Modernising autism spectrum disorder model engineering and treatment via CRISPR-Cas9: A gene reprogramming approach. World J Clin Cases 2023; 11(14): 3114-3127
URL	https://www.wjgnet.com/2307-8960/full/v11/i14/3114.htm
DOI	https://dx.doi.org/10.12998/wjcc.v11.i14.3114

Full Article (PDF)	WJCC-11-3114.pdf
Full Article (Word)	WJCC-11-3114.docx
Manuscript File	82809_Auto_Edited-LiL-Filipodia-JLW.docx
Answering Reviewers	82809-Answering reviewers.pdf
Audio Core Tip	82809-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	82809-Conflict-of-interest statement.pdf
Copyright License Agreement	82809-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	82809-Language certificate.pdf
Peer-review Report	82809-Peer-review(s).pdf
Scientific Misconduct Check	82809-Bing-Li L-2.png
Scientific Editor Work List	82809-Scientific editor work list.pdf