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Articles Published Processes
5/16/2023 9:24:22 AM | Browse: 217 | Download: 488
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Received |
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2022-12-28 04:26 |
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Peer-Review Started |
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2022-12-28 04:28 |
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To Make the First Decision |
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Return for Revision |
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2023-01-30 08:14 |
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Revised |
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2023-02-13 06:02 |
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Second Decision |
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2023-04-06 03:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-04-06 08:06 |
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Articles in Press |
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2023-04-06 08:06 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-04-02 18:36 |
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Typeset the Manuscript |
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2023-04-25 07:56 |
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Publish the Manuscript Online |
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2023-05-16 09:24 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Opinion Review |
| Article Title |
Modernising autism spectrum disorder model engineering and treatment via CRISPR-Cas9: A gene reprogramming approach
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Arushi Sandhu, Anil Kumar, Kajal Rawat, Vipasha Gautam, Antika Sharma and Lekha Saha |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Lekha Saha, MBBS, MD, MNAMS, Full Professor, Professor, Department of Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh 0172, Chandigarh, India. lekhasaha@rediffmail.com |
| Key Words |
Autism spectrum disorder; CRISPR-Cas9; Cellular models; Organoids; Animal models; Therapeutic strategies |
| Core Tip |
There are several reviews in the literature explaining the underlying mechanisms contributing to the pathophysiology of autism spectrum disorder by performing several preclinical experiments. Given the significant role of genetics (de novo or inheritable) in the development of autism spectrum disorder, disease specific models should be established for investigating the mechanism involved. Therefore, this review specifically focused on the use of an emerging genomic editing tool, clustered regularly inters-paced palindromic repeats/Cas9, for generating different types of preclinical models as well as new therapeutic options, providing a novel insight into the disease. |
| Publish Date |
2023-05-16 09:24 |
| Citation |
Sandhu A, Kumar A, Rawat K, Gautam V, Sharma A, Saha L. Modernising autism spectrum disorder model engineering and treatment via CRISPR-Cas9: A gene reprogramming approach. World J Clin Cases 2023; 11(14): 3114-3127 |
| URL |
https://www.wjgnet.com/2307-8960/full/v11/i14/3114.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v11.i14.3114 |
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