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Articles Published Processes
4/26/2023 8:16:12 AM | Browse: 268 | Download: 597
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Received |
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2022-12-28 17:23 |
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Peer-Review Started |
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2022-12-28 17:24 |
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To Make the First Decision |
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Return for Revision |
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2023-01-09 21:43 |
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Revised |
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2023-01-25 11:59 |
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Second Decision |
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2023-03-15 03:07 |
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Accepted by Journal Editor-in-Chief |
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2023-03-16 00:31 |
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Accepted by Executive Editor-in-Chief |
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2023-03-27 11:49 |
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Articles in Press |
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2023-03-27 11:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-04-18 04:23 |
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Publish the Manuscript Online |
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2023-04-26 08:16 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Review |
| Article Title |
Mechanisms of analgesic effect of mesenchymal stem cells in osteoarthritis pain
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fatimah Almahasneh, Ejlal Abu-El-Rub and Ramada R Khasawneh |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| None |
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| Corresponding Author |
Ejlal Abu-El-Rub, PhD, Assistant Professor, Basic Medical Sciences, Faculty of medicine -Yarmouk University, Irbid-Shafiq Irshidat Street, Irbid 21163, Jordan. ejlal.abuelrub@yu.edu.jo |
| Key Words |
Osteoarthritis; Pain; Inflammation; Mesenchymal stem cells; Regeneration; Analgesic mechanisms |
| Core Tip |
Osteoarthritis (OA) is the most common musculoskeletal disease, and it is a major cause of pain, disability and economic burden. Pain is the most common and bothersome presentation of OA, but its treatment is still suboptimal, which highlights the need for new analgesic agents for OA. Mesenchymal stem cells (MSCs) have been extensively investigated as a potential therapy for OA due to their regenerative and anti-inflammatory properties. The administration of MSCs resulted in significant improvement in joint pathology and function, pain scores and/or quality of life in numerous preclinical and clinical studies. Only a limited number of studies, however, addressed pain control as the primary end-point or investigated the potential mechanisms of analgesia induced by MSCs. So, this paper reviews literature for evidence of analgesic actions of MSCs in OA, and summarizes the potential mechanisms of these anti-nociceptive effects |
| Publish Date |
2023-04-26 08:16 |
| Citation |
Almahasneh F, Abu-El-Rub E, Khasawneh RR. Mechanisms of analgesic effect of mesenchymal stem cells in osteoarthritis pain. World J Stem Cells 2023; 15(4): 196-208 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i4/196.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i4.196 |
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