| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Metronomic capecitabine inhibits liver transplant rejection in rats by triggering recipients’ T cell ferroptosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hao Wang, Zheng-Lu Wang, Sai Zhang, De-Jun Kong, Rui-Ning Yang, Lei Cao, Jian-Xi Wang, Sei Yoshida, Zhuo-Lun Song, Tao Liu, Shun-Li Fan, Jia-Shu Ren, Jiang-Hong Li, Zhong-Yang Shen and Hong Zheng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program of China |
2020YFA0710802 |
| The Youth Science Fund of the Nature Science Foundation of Tianjin |
20JCQNJC01370 |
| The Key Projects of Tianjin Science and Technology Project |
21JCZDJC00160 |
| The Science Foundation of Tianjin Health Commission |
ZC20065 |
| The Science Foundation of Tianjin Health Commission |
ZC20089 |
|
| Corresponding Author |
Hong Zheng, PhD, Professor, Department of Organ Transplant, Tianjin First Central Hospital, School of Medicine, Nankai University, No. 24 Fukang Road, Nankai District, Tianjin 300190, China. zhenghongyx@139.com |
| Key Words |
Capecitabine; Ferroptosis; T Lymphocytes, Immunosuppressive agents; Graft rejection; Liver transplantation |
| Core Tip |
Our studies proved that metronomic capecitabine (CAP) alleviated the acute rejection after transplantation in rats without the common side effect of myelosuppression. T cell ferroptosis is the underlying mechanism behind the antirejection effect of CAP, which can induce cell ferrous ions overload and suppress the nuclear erythroid 2 p45-related factor 2, heme oxygenase-1/glutathione peroxidase 4 antioxidant systems, thereby directly increasing the levels of intracellular reactive oxygen species, and leading to severe oxidative damage in T cells. These results revealed a new mechanism of CAP-induced T cell programmed death and suggested the possibility of using CAP as an immunosuppressant after transplantation. |
| Publish Date |
2023-05-26 08:34 |
| Citation |
Wang H, Wang ZL, Zhang S, Kong DJ, Yang RN, Cao L, Wang JX, Yoshida S, Song ZL, Liu T, Fan SL, Ren JS, Li JH, Shen ZY, Zheng H. Metronomic capecitabine inhibits liver transplant rejection in rats by triggering recipients’ T cell ferroptosis. World J Gastroenterol 2023; 29(20): 3084-3102 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i20/3084.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i20.3084 |
