| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Review |
| Article Title |
Communication between bone marrow mesenchymal stem cells and multiple myeloma cells: Impact on disease progression
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Daniel García-Sánchez, Alberto González-González, Ana Alfonso-Fernández, Mónica Del Dujo-Gutiérrez and Flor M Pérez-Campo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The “Instituto de Salud Carlos III |
PI22/00264 |
| A Predoctoral Program in Biomedicine from The University of Cantabria and The Instituto de Investigación Valdecilla-IDIVAL (Alberto González-González and Daniel García-Sánchez) |
PREVAL19/02 |
| A Predoctoral Program in Biomedicine from The University of Cantabria and The Instituto de Investigación Valdecilla-IDIVAL (Alberto González-González and Daniel García-Sánchez) |
PREVAL20/01 |
| “Investigo Program”, part of the “Plan Nacional de Recuperación, Transformación y Resiliencia” from The Spanish Government (Mónica del Dujo-Gutiérrez) |
|
|
| Corresponding Author |
Flor M Pérez-Campo, MSc, PhD, Assistant Professor, Senior Scientist, Department of Molecular Biology_IDIVAL, Faculty of Medicine, University of Cantabria, Avda Cardenal Herrera Oria S/N, Santander 39011, Cantabria, Spain. f.perezcampo@unican.es |
| Key Words |
Multiple Myeloma; Mesenchymal stem cells; Bone marrow microenvironment; Soluble factors; Extra-cellular vesicles; Cells adhesion molecules; Tunnelling-nanotubes |
| Core Tip |
Mesenchymal stem cells (MSCs), the main cell population of the bone marrow (BM) stroma, can influence the BM microenvironment, through their paracrine activity, involving both soluble factors and extracellular vesicles, but also through direct communication. Being the BM the predominant localization of multiple myeloma cells (MM), finding the appropriate conditions at this niche, is key for the survival and expansion of tumour cells and thus, for the progression of the disease. Since the activity of BM-MSCs could determines the fate of MM cells at BM, these cells could be interesting targets for the design of new antitumor drugs. |
| Publish Date |
2023-05-26 11:17 |
| Citation |
García-Sánchez D, González-González A, Alfonso-Fernández A, Del Dujo-Gutiérrez M, Pérez-Campo FM. Communication between bone marrow mesenchymal stem cells and multiple myeloma cells: Impact on disease progression. World J Stem Cells 2023; 15(5): 421-437 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i5/421.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i5.421 |
