| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Retrospective Study |
| Article Title |
Ability of lactulose breath test results to accurately identify colorectal polyps through the measurement of small intestine bacterial overgrowth
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lan Li, Xue-Yuan Zhang, Jin-Sheng Yu, Hui-Min Zhou, Yan Qin, Wen-Rui Xie, Wen-Jing Ding and Xing-Xiang He |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Key-Area Research and Development Program of Guangdong Province |
2022B1111070006 |
| The Guangdong Innovation Research Team for Higher Education |
2021KCXTD025 |
|
| Corresponding Author |
Xing-Xiang He, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, No. 19 Nonglinxia Road, Guangzhou 510080, Guangdong Province, China. hexingxiang@gdpu.edu.cn |
| Key Words |
Lactulose breath test; Colorectal polyp; Small intestine bacteria overgrowth; Intestinal barrier function; Retrospective study |
| Core Tip |
As the lactulose breath test (LBT) is an indirect method of measuring bacteria in the digestive tract, it is primarily used to support small intestine bacteria overgrowth (SIBO) diagnosis but is implemented as a new method for screening colorectal polyps in this study. A total of 382 patients with LBT results were classified into polyp and non-polyp groups that were confirmed by colonoscopy and pathology. First, it applied the LBT for assessment of its utility as a noninvasive screening tool for colorectal polyps as well as for diagnosis of SIBO. Second, the results revealed certain key associations among colorectal polyps, SIBO and Intestinal barrier function damage (IBFD), such as SIBO was more prevalent in patients with colorectal polyp than those without polyp and IBFD was more susceptible in patients with colorectal polyp than those without polyp only when SIBO was evident. Third, in regression analysis with age and gender adjustment, colorectal polyp was best predicted by models using plain methane peak values or combined hydrogen and methane values limited by the North American Consensus for SIBO. One of the most important result was moderate potential of LBT as an alternative noninvasive screening tool for colorectal polyps. |
| Publish Date |
2023-06-15 12:09 |
| Citation |
Li L, Zhang XY, Yu JS, Zhou HM, Qin Y, Xie WR, Ding WJ, He XX. Ability of lactulose breath test results to accurately identify colorectal polyps through the measurement of small intestine bacterial overgrowth. World J Gastrointest Surg 2023; 15(6): 1138-1148 |
| URL |
https://www.wjgnet.com/1948-9366/full/v15/i6/1138.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v15.i6.1138 |
