Publication Name	World Journal of Gastroenterology
Manuscript ID	8355
Country	China

Received	2013-12-26 16:08
Peer-Review Started	2013-12-27 10:02
To Make the First Decision	2014-01-15 11:15
Return for Revision	2014-01-20 10:45
Revised
Second Decision	2014-04-23 09:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-23 10:16
Articles in Press	2014-05-23 10:35
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-15 16:49
Typeset the Manuscript	2014-08-28 09:43
Publish the Manuscript Online	2014-08-29 11:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Autobiography
Article Title	Effect of GP73 silencing on proliferation and apoptosis in hepatocellular cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Long Zhang, You-Cheng Zhang, Wei Han, Yu-Min Li, Geng-Nian Wang, Shao Yuan, Feng-Xian Wei, Jia-Feng Wang, Jian-Jun Jiang and Ya-Wu Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Gansu Provincial-level Key Laboratory of Digestive System Tumors Open projects Research Fund lzujbky-2011-t03
Corresponding Author	Correspondence to: You-Cheng Zhang, MD, PhD, Department of General Surgery, Lanzhou University Second Hospital, Cuiyingmen 82, Chengguan District, Lanzhou 730030, Gansu Province, China. zhangyouchengphd@163.com
Key Words	Hepatocellular carcinoma; Golgi protein-73; Cell proliferation; Apoptosis
Core Tip	Stealth RNAi targeting Golgi protein (GP)73 gene sequence markedly reduced the expression of GP73 gene. Reduction of GP73 in Hep G2 cells and Bel7402 cells inhibited cell proliferation and induced apoptosis, however, terminal apoptosis occurred in Hep G2 cells, but early apoptosis occurred in Bel7402 cells. Reduced expression of GP73 gene might lead to a reduction in Bcl-2/ Bax ratio, an increase in cytochrome c, but a reduction in capase-3. GP73 might play an important role in proliferation and apoptosis in Hep G2 and Bel7402 cells.
Publish Date	2014-08-29 11:57
Citation	Zhang YL, Zhang YC, Han W, Li YM, Wang GN, Yuan S, Wei FX, Wang JF, Jiang JJ, Zhang YW. Effect of GP73 silencing on proliferation and apoptosis in hepatocellular cancer. World J Gastroenterol 2014; 20(32): 11287-11296
URL	http://www.wjgnet.com/1007-9327/full/v20/i32/11287.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i32.11287

Full Article (PDF)	WJG-20-11287.pdf
Full Article (Word)	WJG-20-11287.doc
Manuscript File	8355-Review.doc
Answering Reviewers	8355-Answering reviewers.pdf
Copyright License Agreement	8355-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8355-Language certificate.pdf
Peer-review Report	8355-Peer reviews.pdf
Scientific Editor Work List	8355-Scientific editor work list.doc