Publication Name	World Journal of Gastroenterology
Manuscript ID	8374
Country	Japan

Received	2013-12-27 19:32
Peer-Review Started	2013-12-28 14:14
To Make the First Decision	2014-01-09 14:50
Return for Revision	2014-01-17 15:29
Revised	2014-03-08 09:52
Second Decision	2014-07-16 12:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-16 13:03
Articles in Press	2014-07-16 17:53
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-26 16:42
Typeset the Manuscript	2014-10-28 10:13
Publish the Manuscript Online	2014-11-10 19:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Linker phosphorylation of Smad3 promotes fibro-carcinogenesis in chronic viral hepatitis of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Miki Murata, Katsunori Yoshida, Takashi Yamaguchi and Koichi Matsuzaki
Funding Agency and Grant Number
Corresponding Author	Miki Murata, MD, Department of Gastroenterology and Hepatology, Kansai Medical University, 10-15 Fumizonocho, Moriguchi, Osaka 570-8506, Japan. muratami@takii.kmu.ac.jp
Key Words	Chronic viral hepatitis; Transforming growth factor-; Smad3; Phosphorylation; Fibro-carcinogenesis; Hepatocellular carcinoma
Core Tip	Chronic hepatitis B and C infections are major causes of cirrhosis and hepatocellular carcinoma (HCC). Most patients with persistent viral infection remain asymptomatic, while some patients have poor prognosis and develop HCC. Therefore, identifying persons at high-HCC risk among chronic hepatitis patients is crucial for preventing HCC. Analyses of domain-specific phosphorylation of Smad3 in liver specimens can be helpful to understand the stages of diseases and might represent a marker to predict HCC development.
Publish Date	2014-11-10 19:10
Citation	Murata M, Yoshida K, Yamaguchi T, Matsuzaki K. Linker phosphorylation of Smad3 promotes fibro-carcinogenesis in chronic viral hepatitis of hepatocellular carcinoma. World J Gastroenterol 2014; 20(41): 15018-15027
URL	http://www.wjgnet.com/1007-9327/full/v20/i41/15018.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i41.15018

Full Article (PDF)	WJG-20-15018.pdf
Full Article (Word)	WJG-20-15018.doc
Manuscript File	8374-Review.docx
Answering Reviewers	8374-Answering reviewers.pdf
Copyright License Agreement	8374-Copyright assignment.pdf
Peer-review Report	8374-Peer reviews.pdf
Scientific Misconduct Check	8374-CrossCheck.jpg
Scientific Editor Work List	8374-Scientific editor work list.pdf