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Articles Published Processes
6/7/2023 6:39:13 AM | Browse: 477 | Download: 1401
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Received |
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2023-02-27 23:21 |
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Peer-Review Started |
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2023-02-27 23:25 |
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First Decision by Editorial Office Director |
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2023-04-03 04:23 |
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Return for Revision |
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2023-04-03 04:23 |
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Revised |
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2023-04-25 23:23 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-05-12 03:07 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-05-12 09:21 |
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Articles in Press |
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2023-05-12 09:21 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-05-29 09:31 |
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Publish the Manuscript Online |
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2023-06-07 06:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Anatomy & Morphology |
| Manuscript Type |
Basic Study |
| Article Title |
Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Henrique Inhauser Riceti Magalhães, Felipe Alexandre Machado, Roberta Figueiroa Souza, Marcos Antônio Ferreira Caetano, Vanessa Ribeiro Figliuolo, Robson Coutinho-Silva and Patricia Castelucci |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Council for Scientific and Technological Development |
No. 168015/2018-8 |
| São Paulo Research Foundation |
No. 2014/25927-2 and No. 2018/07862-1 |
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| Corresponding Author |
Patricia Castelucci, MHSc, PhD, Associate Professor, Associate Research Scientist, Lecturer, Department of Anatomy, University of São Paulo, 2415, Av. Dr Lineu Prestes, São Paulo 05508-000, Brazil. pcastel@usp.br |
| Key Words |
Cell death; Enteric nervous system; Gastroenterology; Inflammatory bowel diseases; P2X7 receptor; Purinergic signaling |
| Core Tip |
In the present study, we compared pathological changes resulting from 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis at two different time points after colitis induction. At both 24 h and four days post-inflammatory induction, there was a decrease in the number of myenteric neurons in the wild-type groups but not in the knockout groups. Morphometric and ultrastructural changes were also observed. In addition, our results confirm that neuronal death mediated by caspase-3 activation is related to purinergic signaling via the P2X7 receptor in the myenteric plexus of mice with TNBS-induced colitis. |
| Publish Date |
2023-06-07 06:39 |
| Citation |
Magalhães HIR, Machado FA, Souza RF, Caetano MAF, Figliuolo VR, Coutinho-Silva R, Castelucci P. Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis. World J Gastroenterol 2023; 29(22): 3440-3468 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i22/3440.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i22.3440 |
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