Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	8432
Country	India

Received	2013-12-28 13:58
Peer-Review Started	2013-12-28 18:11
To Make the First Decision	2014-01-23 17:20
Return for Revision	2014-02-24 10:35
Revised	2014-03-13 16:44
Second Decision	2014-10-16 15:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-16 15:45
Articles in Press	2014-10-16 15:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-22 21:33
Publish the Manuscript Online	2014-11-19 10:25

ISSN	2150-5330 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Genetics of acute and chronic pancreatitis: An update
Manuscript Source	Invited Manuscript
All Author List	VV Ravi Kanth and D Nageshwar Reddy
Funding Agency and Grant Number
Corresponding Author	Dr. D Nageshwar Reddy, Director, Asian Institute of Gastroenterology and Asian Healthcare Foundation, 6-3-661, Somajiguda, Hyderabad 500082, India. aigindia@yahoo.co.in
Key Words	Chronic pancreatitis; Acute pancreatitis; Genetic susceptibility; Single nucleotide polymorphisms; Inflammation
Core Tip	Pancreatitis is a progressive inflammatory disease. Though the pancreas has adequate protection against environmental and metabolic stress, if the magnitude of this stress exceeds the threshold which the organ can handle, it leads to pathologic effects. Although genetic variables have been identified that affect the function of pancreas, namely polymorphisms in serine protease inhibitor kazal type 1 (SPINK1), polymorphisms in cationic trypsinogen (PRSS1) and Chymotrypsinogen C (CTRC) genes in the acinar cells and cystic fibrosis trans-membrane conductance regulator (CFTR), calcium sensing receptor (CASR genes in the ductal cells leading to pancreatitis, off late many genetic factors outside of the “intra-pancreatic trypsin regulatory mechanism” have been identified for their role in pancreatitis. This review is an update on the genetic aspects of acute and chronic pancreatitis.
Publish Date	2014-11-19 10:25
Citation	Ravi Kanth VV, Nageshwar Reddy D. Genetics of acute and chronic pancreatitis: An update. World J Gastrointest Pathophysiol 2014; 5(4): 427-437
URL	http://www.wjgnet.com/2150-5330/full/v5/i4/427.htm
DOI	http://dx.doi.org/10.4291/wjgp.v5.i4.427

Full Article (PDF)	WJGP-5-427.pdf
Full Article (Word)	WJGP-5-427.doc
Manuscript File	8432-Review.docx
Answering Reviewers	8432-Answering reviewers.pdf
Copyright License Agreement	8432-Copyright assignment.pdf
Peer-review Report	8432-Peer review(s).pdf
Scientific Misconduct Check	8432-CrossCheck.jpg
Scientific Editor Work List	8432-Scientific editor work list.pdf