| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Transplantation of human induced pluripotent stem cell derived keratinocytes accelerates deep second-degree burn wound healing
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Jun Wu, Wei Lin, Jian-Jiang Liu, Wei-Xin Chen, Wen-Jun He, Yuan Shi, Xiao Liu and Ke Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Hospital Research Fund |
SDFEYBS1805, SDFEYGJ2013 and XKTJ-HRC20210015 |
| Suzhou Science and Technology Development Project |
SYS2020105, SKJY2021078 and 2022SS43 |
| CNNC Elite Talent Program |
|
| 2022 State Key Laboratory of Radiological Medicine and Radiation Protection jointly built by Province and Ministry |
GZK1202244 |
|
| Corresponding Author |
Ke Li, MM, Academic Research, Department of Burn and Plastic Surgery, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou 215006, Jiangsu Province, China. likefggf@163.com |
| Key Words |
Induced pluripotent stem cell; Keratinocytes; Cell transplantation; Burn wound healing; COL7A1 |
| Core Tip |
Current evidence shows that human induced pluripotent stem cells (hiPSCs) can effectively differentiate into keratinocytes (KCs), but its effect on skin burn healing has not been reported. Therefore, this study was intended to observe the effects of hiPSCs-derived KCs transplantation on skin burn healing in mice and to preliminarily reveal the underlying mechanisms. Transplantation of hiPSCs-KCs into mice with burn wounds resulted in a significant decrease in wound area, an increase in wound re-epithelialization, a decrease in proinflammatory factors content, and an inhibition of NF-κB pathway activation, which rescued by COL7A1 knockdown. |
| Publish Date |
2023-07-25 06:43 |
| Citation |
Wu LJ, Lin W, Liu JJ, Chen WX, He WJ, Shi Y, Liu X, Li K. Transplantation of human induced pluripotent stem cell derived keratinocytes accelerates deep second-degree burn wound healing. World J Stem Cells 2023; 15(7): 713-733 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i7/713.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i7.713 |
