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Articles Published Processes
7/21/2023 9:10:50 AM | Browse: 169 | Download: 709
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Received |
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2023-03-27 08:10 |
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Peer-Review Started |
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2023-03-27 08:12 |
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To Make the First Decision |
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Return for Revision |
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2023-04-19 22:26 |
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Revised |
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2023-05-17 15:50 |
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Second Decision |
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2023-06-12 02:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-06-12 09:25 |
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Articles in Press |
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2023-06-12 09:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-06-15 05:44 |
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Publish the Manuscript Online |
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2023-07-21 09:10 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Liver stiffness in pregnant women with intrahepatic cholestasis of pregnancy: A case control study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Juliane Nees, Franziska J Ammon, Johannes Mueller, Herbert Fluhr and Sebastian Mueller |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Faculty of Medicine Heidelberg in The Form of The Rahel-Goitein-Strauss Fellowship to JN |
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| Corresponding Author |
Sebastian Mueller, PhD, Professor, Center for Alcohol Research, University Hospital Heidelberg, Im Neuenheimer Feld 350, Heidelberg 69120, Germany. sebastian.mueller@urz.uni-heidelberg.de |
| Key Words |
Intrahepatic cholestasis of pregnancy; Transient elastography; Bile acids; Liver stiffness; High risk pregnancy |
| Core Tip |
Intrahepatic cholestasis of pregnancy (ICP) is a rare but severe complication in both mothers and unborn children. In a large ICP cohort, we studied liver stiffness (LS) in detail using transient elastography, which is now widely used for non-invasive screening of liver cirrhosis within minutes. LS is significantly elevated in pregnancies with ICP, most likely owing to toxic bile acid accumulation and hepatocyte apoptosis. Interestingly, no correlation was observed with γ-glutamyl transferase. In association with conventional laboratory markers, LS provides a novel non-invasive tool to rapidly identify women at risk for pregnancy complications. |
| Publish Date |
2023-07-21 09:10 |
| Citation |
Nees J, Ammon FJ, Mueller J, Fluhr H, Mueller S. Liver stiffness in pregnant women with intrahepatic cholestasis of pregnancy: A case control study. World J Hepatol 2023; 15(7): 904-914 |
| URL |
https://www.wjgnet.com/1948-5182/full/v15/i7/904.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v15.i7.904 |
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