| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Islet transplantation-immunological challenges and current perspectives
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Plamena Kabakchieva, Yavor Assyov, Stavros Gerasoudis, Georgi Vasilev, Monika Peshevska-Sekulovska, Metodija Sekulovski, Snezhina Lazova, Dimitrina Georgieva Miteva, Milena Gulinac, Latchezar Tomov and Tsvetelina Velikova |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| European Union-NextGenerationEU, through The National Recovery and Resilience Plan of the Republic of Bulgaria |
BG-RRP-2.004-0008-C01 |
|
| Corresponding Author |
Plamena Kabakchieva, MD, PhD, Academic Research, Assistant Professor, Clinic of Internal Diseases, Naval Hospital-Varna, Military Medical Academy, No. 3 Hristo Smirnenski Blvd, Varna 9010, Bulgaria. plamenakabakchieva@yahoo.com |
| Key Words |
Islet transplantation; Type 1 diabetes; Diabetes mellitus; Immune tolerance; Graft rejection; T regulatory cells; B regulatory cells |
| Core Tip |
Type 1 diabetes (T1D) is associated with loss of beta-cell mass and insulin secretion. Regardless of its nature, autoimmune or idiopathic, the loss of own insulin secretion is a hallmark dysfunction in T1D mellitus; thus, therapeutic options are aimed at either replacing the missing insulin or restoring physiological insulin secretion to achieve normoglycemia and postponing micro- and macrovascular complications. Nevertheless, the need to completely replace the depleted pancreatic secretion also leads to the emergence of new therapeutic horizons, including pancreas and islet cell transplantation. However, this approach also meets several immunological challenges-cellular and antibody-mediated rejection and loss of function. To improve the outcomes, several approaches are performed: Immunosuppression, apoptotic donor lymphocytes, anti-TIM-1 antibodies, mixed chimerism-based tolerance induction, induction of antigen-specific tolerance utilizing ethylene carbodiimide-fixed splenocytes, infusion of donor apoptotic cells before transplantation, combined with anti-CD40L antibodies and rapamycin, preconditioning of isolated islets, inducing local immunotolerance, cell encapsulation and immunoisolation, using of biomaterials, immunomodulatory cells, etc. mesenchymal stem cells, as an adjunct therapy to islet transplantation, can promote long-term graft survival, possibly by reducing inflammation and enhancing immune tolerance. |
| Publish Date |
2023-06-16 07:59 |
| Citation |
Kabakchieva P, Assyov Y, Gerasoudis S, Vasilev G, Peshevska-Sekulovska M, Sekulovski M, Lazova S, Miteva DG, Gulinac M, Tomov L, Velikova T. Islet transplantation-immunological challenges and current perspectives. World J Transplant 2023; 13(4): 107-121 |
| URL |
https://www.wjgnet.com/2220-3230/full/v13/i4/107.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v13.i4.107 |
