Publication Name	World Journal of Diabetes
Manuscript ID	84803
Country	China

Received	2023-03-28 12:32
Peer-Review Started	2023-03-28 12:32
To Make the First Decision
Return for Revision	2023-07-04 06:54
Revised	2023-07-11 14:47
Second Decision	2023-07-31 03:05
Accepted by Journal Editor-in-Chief	2023-08-04 05:20
Accepted by Executive Editor-in-Chief	2023-09-06 08:02
Articles in Press	2023-09-06 08:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-09-28 03:09
Publish the Manuscript Online	2023-11-14 06:13

ISSN	1948-9358 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Vascular endothelial growth factor B improves impaired glucose tolerance through insulin-mediated inhibition of glucagon secretion
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Qi Li, Lu-Yang Zhang, Yu-Chi Zhao, Fang Xu, Zhi-Yong Hu, Qi-Hao Wu, Wen-Hao Li and Ya-Nuo Li
ORCID	Author(s) ORCID Number Yu-Qi Li http://orcid.org/0000-0003-0236-8581 Lu-Yang Zhang http://orcid.org/0009-0003-7813-0024 Yu-Chi Zhao http://orcid.org/0000-0002-4776-1419 Fang Xu http://orcid.org/0000-0002-2725-8533 Zhi-Yong Hu http://orcid.org/0000-0001-6855-2838 Qi-Hao Wu http://orcid.org/0009-0006-7709-6313 Wen-Hao Li http://orcid.org/0009-0001-8920-2455 Ya-Nuo Li http://orcid.org/0000-0002-6441-5024
Funding Agency and Grant Number	Funding Agency Grant Number The National Natural Science Foundation of China 31771284 The Basic Research Project of Yantai Science and Technology Innovation and Development Plan 2022JCYJ026 The Natural Science Foundation of Shandong province ZR202111250163 Yantai Science and Technology Plan Project 2022YD062
Corresponding Author	Ya-Nuo Li, PhD, Professor, Department of Pathophysiology, School of Basic Medicine, Binzhou Medical University, No. 346 Guanhai Road, Laishan District, Yantai 264000, Shandong Province, China. liyanuo@bzmc.edu.cn
Key Words	Vascular endothelial growth factor B; Insulin-mediated; Glucagon secretion; Prediabetes; Impaired glucose tolerance
Core Tip	Impaired glucose tolerance (IGT) is an abnormal metabolic stage between the normal state and diabetes, which belongs to prediabetes. Therefore, intervention in IGT can effectively reduce the incidence rate of diabetes. The pathological mechanism of IGT is related to glucose homeostasis imbalance and decreased insulin sensitivity. Currently, vascular endothelial growth factor B (VEGFB) has been reported to have the effect of restoring glucose tolerance and improving insulin sensitivity. Therefore, the use of VEGFB as a target for intervention has become the focus of current research. This research mainly illustrates the role of VEGFB in promoting insulin and glucagon secretion to alleviate IGT and its potential molecular mechanism.
Publish Date	2023-11-14 06:13
Citation	Li YQ, Zhang LY, Zhao YC, Xu F, Hu ZY, Wu QH, Li WH, Li YN. Vascular endothelial growth factor B improves impaired glucose tolerance through insulin-mediated inhibition of glucagon secretion. World J Diabetes 2023; 14(11): 1643-1658
URL	https://www.wjgnet.com/1948-9358/full/v14/i11/1643.htm
DOI	https://dx.doi.org/10.4239/wjd.v14.i11.1643

Full Article (PDF)	WJD-14-1643-with-cover.pdf
Full Article (Word)	WJD-14-1643.docx
Manuscript File	84803_Auto_Edited-JLW.docx
Answering Reviewers	84803-Answering reviewers.pdf
Audio Core Tip	84803-Audio core tip.m4a
Biostatistics Review Certificate	84803-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	84803-Conflict-of-interest statement.pdf
Copyright License Agreement	84803-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	84803-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	84803-Language certificate.pdf
Peer-review Report	84803-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	84803-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	84803-Bing-Chen YL-2.png
Scientific Editor Work List	84803-Scientific editor work list.pdf
CrossCheck Report	84803-CrossCheck report.pdf