Publication Name	World Journal of Orthopedics
Manuscript ID	8512
Country	Germany

Received	2013-12-29 16:28
Peer-Review Started	2013-12-29 19:47
To Make the First Decision	2014-02-27 10:52
Return for Revision	2014-03-04 20:57
Revised	2014-06-20 00:00
Second Decision	2014-07-14 16:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-07-14 17:16
Articles in Press	2014-07-14 17:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-11 08:36
Publish the Manuscript Online	2014-08-20 20:55

ISSN	2218-5836 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Orthopedics
Manuscript Type	Review
Article Title	Metallic debris from metal-on-metal total hip arthroplasty regulates periprosthetic tissues
Manuscript Source	Invited Manuscript
All Author List	Christoph H Lohmann, Gurpal Singh, Hans-Georg Willert and Gottfried H Buchhorn
Funding Agency and Grant Number
Corresponding Author	Christoph H Lohmann, MD, Department of Orthopaedic Surgery, Otto-von-Guericke University, LeipzigerStrasse 44, 39120 Magdeburg, Germany. christoph.lohmann@med.ovgu.de
Key Words	Periprosthetic tissue response; Metal-on-Metal; Total hip arthroplasty; Metal debris; Lymphocyte-dominated; Macrophage-dominated; Taper corrosion; Modularity
Core Tip	Valuable lessons have been learnt from the era of metal-on-metal total hip arthroplasty. We present a review of the concepts introduced by Willert and Semlitsch in 1977, along with further developments made in the understanding of periprosthetic tissue reactions to metallic debris. We propose that periprosthetic tissue reactions be thought of as (1) gross (metallosis, necrosis, cyst formation and pseudotumour); (2) histological (macrophage-dominated, lymphocyte-dominated or mixed); and (3) molecular (expression of inflammatory mediators and cytokines such as interleukin-6 and tumor necrosis factor-alpha). Taper corrosion and modularity is discussed, along with future research directions in this area.
Publish Date	2014-08-20 20:55
Citation	Lohmann CH, Singh G, Willert HG, Buchhorn GH. Metallic debris from metal-on-metal total hip arthroplasty regulates periprosthetic tissues. World J Orthop 2014; 5(5): 660-666
URL	http://www.wjgnet.com/2218-5836/full/v5/i5/660.htm
DOI	http://dx.doi.org/10.5312/wjo.v5.i5.660

Full Article (PDF)	WJO-5-660.pdf
Full Article (Word)	WJO-5-660.doc
Manuscript File	8512-Review.docx
Answering Reviewers	8512-Answering reviewers.pdf
Copyright License Agreement	8512-Copyright assignment.pdf
Peer-review Report	8512-Peer review(s).pdf
Scientific Misconduct Check	8512-CorssCheck.jpg
Scientific Editor Work List	8512-Scientific editor work list.pdf