Publication Name	World Journal of Cardiology
Manuscript ID	85141
Country	China

Received	2023-04-14 02:54
Peer-Review Started	2023-04-14 02:56
To Make the First Decision
Return for Revision	2023-05-22 12:38
Revised	2023-06-01 05:57
Second Decision	2023-06-13 02:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-06-13 08:51
Articles in Press	2023-06-13 08:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-06-20 06:04
Publish the Manuscript Online	2023-06-26 08:56

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Identification of potential biomarkers for idiopathic pulmonary fibrosis and validation of TDO2 as a potential therapeutic target
Manuscript Source	Unsolicited Manuscript
All Author List	Ru Wang and Yan-Mei Yang
ORCID	Author(s) ORCID Number Yan-Mei Yang http://orcid.org/0000-0001-9881-2442
Funding Agency and Grant Number
Corresponding Author	Yan-Mei Yang, PhD, Doctor, Zhengzhou University, Research Centre of Basic Medicine, Academy of Medical Sciences, No. 40 North University Road, Erqi District, Zhengzhou 450000, Henan Province, China. yang_yanmei@gs.zzu.edu.cn
Key Words	Idiopathic pulmonary fibrosis; Lung function; Overall survival; Transforming growth factor-β; TDO2 inhibitor
Core Tip	This study is unique in several aspects: (1) We identified six hub genes for idiopathic pulmonary fibrosis (IPF) and determined through quantitative real-time polymerase chain reaction; (2) Multi-omics analysis proved that TDO2 was upregulated in IPF patients and promoted the IPF proliferation of fibroblasts; (3) TDO2 may be involved in P53 pathway and aggravate aging and persistent pulmonary fibrosis; and (4) TDO2 inhibitor effectively suppressed transforming growth factor-β-induced fibroblast activation.
Publish Date	2023-06-26 08:56
Citation	Wang R, Yang YM. Identification of potential biomarkers for idiopathic pulmonary fibrosis and validation of TDO2 as a potential therapeutic target. World J Cardiol 2023; 15(6): 293-308
URL	https://www.wjgnet.com/1949-8462/full/v15/i6/293.htm
DOI	https://dx.doi.org/10.4330/wjc.v15.i6.293

Full Article (PDF)	WJC-15-293-with-cover.pdf
Full Article (Word)	WJC-15-293.docx
Manuscript File	85141_Auto_Edited-JLW.docx
Answering Reviewers	85141-Answering reviewers.pdf
Audio Core Tip	85141-Audio core tip.wav
Biostatistics Review Certificate	85141-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	85141-Conflict-of-interest statement.pdf
Copyright License Agreement	85141-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	85141-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	85141-Language certificate.pdf
Supplementary Material	85141-Supplementary material.pdf
Peer-review Report	85141-Peer-review(s).pdf
Scientific Misconduct Check	85141-Bing-Fan JR-2.png
Scientific Editor Work List	85141-Scientific editor work list.pdf