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Articles Published Processes
6/26/2023 8:56:35 AM | Browse: 292 | Download: 1244
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Received |
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2023-04-14 02:54 |
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Peer-Review Started |
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2023-04-14 02:56 |
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First Decision by Editorial Office Director |
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2023-05-17 18:36 |
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Return for Revision |
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2023-05-22 12:38 |
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Revised |
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2023-06-01 05:57 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-06-13 02:58 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-06-13 08:51 |
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Articles in Press |
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2023-06-13 08:51 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-06-20 06:04 |
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Publish the Manuscript Online |
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2023-06-26 08:56 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Identification of potential biomarkers for idiopathic pulmonary fibrosis and validation of TDO2 as a potential therapeutic target
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ru Wang and Yan-Mei Yang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yan-Mei Yang, PhD, Doctor, Doctor, Zhengzhou University, Research Centre of Basic Medicine, Academy of Medical Sciences, No. 40 North University Road, Erqi District, Zhengzhou 450000, Henan Province, China. yang_yanmei@gs.zzu.edu.cn |
| Key Words |
Idiopathic pulmonary fibrosis; Lung function; Overall survival; Transforming growth factor-β; TDO2 inhibitor |
| Core Tip |
This study is unique in several aspects: (1) We identified six hub genes for idiopathic pulmonary fibrosis (IPF) and determined through quantitative real-time polymerase chain reaction; (2) Multi-omics analysis proved that TDO2 was upregulated in IPF patients and promoted the IPF proliferation of fibroblasts; (3) TDO2 may be involved in P53 pathway and aggravate aging and persistent pulmonary fibrosis; and (4) TDO2 inhibitor effectively suppressed transforming growth factor-β-induced fibroblast activation. |
| Publish Date |
2023-06-26 08:56 |
| Citation |
Wang R, Yang YM. Identification of potential biomarkers for idiopathic pulmonary fibrosis and validation of TDO2 as a potential therapeutic target. World J Cardiol 2023; 15(6): 293-308 |
| URL |
https://www.wjgnet.com/1949-8462/full/v15/i6/293.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v15.i6.293 |
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