Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	85245
Country	China

Received	2023-04-19 10:00
Peer-Review Started	2023-04-19 10:02
To Make the First Decision
Return for Revision	2023-06-20 19:21
Revised	2023-06-29 16:33
Second Decision	2023-07-24 03:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-07-29 21:27
Articles in Press	2023-07-29 21:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-10-01 04:25
Typeset the Manuscript	2023-11-03 08:20
Publish the Manuscript Online	2023-11-15 13:46

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Dopamine and cyclic adenosine monophosphate-regulated phosphoprotein with an apparent Mr of 32000 promotes colorectal cancer growth
Manuscript Source	Unsolicited Manuscript
All Author List	Kuan He, Chao-Zheng Xie, Ya Li, Zhen-Zhou Chen, Shi-Hao Xu, Si-Qi Huang, Jian-Guo Yang, Zheng-Qiang Wei and Xu-Dong Peng
ORCID	Author(s) ORCID Number Xu-Dong Peng http://orcid.org/0000-0002-3151-9601
Funding Agency and Grant Number	Funding Agency Grant Number Chongqing Key Diseases Research and Application Demonstration Program No. 2019ZX003 General Project of Chongqing Nature Science Foundation No. cstc2021jcyj-msxmX0283
Corresponding Author	Xu-Dong Peng, PhD, Doctor, Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing 400000, China. 846393577@qq.com
Key Words	Colorectal cancer; Dopamine and cyclic adenosine monophosphate-regulated phosphoprotein with an apparent Mr of 32000; Proliferation; Migration; Phosphoinositide 3-kinase; Akt
Core Tip	Dopamine and cyclic adenosine monophosphate-regulated phosphoprotein with an apparent Mr of 32000 (DARPP-32) is frequently upregulated in colorectal cancer (CRC). Overexpression of DARPP-32 promotes cancer cell proliferation, migration, invasion and reduces apoptosis. Mechanistic investigations reveal that DARPP-32 may exert its oncogenic functions through regulation of the phosphoinositide 3-kinase/AKT signaling pathway which is involved in cell survival and proliferation. These findings indicate that DARPP-32 plays an essential role in facilitating colorectal tumorigenesis and progression. Therefore, DARPP-32 may represent a potential novel biomarker and therapeutic target for CRC treatment.
Publish Date	2023-11-15 13:46
Citation	He K, Xie CZ, Li Y, Chen ZZ, Xu SH, Huang SQ, Yang JG, Wei ZQ, Peng XD. Dopamine and cyclic adenosine monophosphate-regulated phosphoprotein with an apparent Mr of 32000 promotes colorectal cancer growth. World J Gastrointest Oncol 2023; 15(11): 1936-1950
URL	https://www.wjgnet.com/1948-5204/full/v15/i11/1936.htm
DOI	https://dx.doi.org/10.4251/wjgo.v15.i11.1936

Full Article (PDF)	WJGO-15-1936-with-cover.pdf
Full Article (Word)	WJGO-15-1936.docx
Manuscript File	85245-Review-Filipodia.docx
Answering Reviewers	85245-Answering reviewers.pdf
Audio Core Tip	85245-Audio core tip.mp3
Biostatistics Review Certificate	85245-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	85245-Conflict-of-interest statement.pdf
Copyright License Agreement	85245-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	85245-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	85245-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	85245-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	85245-Language certificate.pdf
Supplementary Material	85245-Supplementary material.pdf
Peer-review Report	85245-Peer-review(s).pdf
Scientific Misconduct Check	85245-Bing-Qu XL-2.png
Scientific Editor Work List	85245-Scientific editor work list.pdf