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Articles Published Processes
9/8/2023 9:38:26 AM | Browse: 322 | Download: 1071
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Received |
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2023-05-06 20:05 |
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Peer-Review Started |
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2023-05-06 20:08 |
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First Decision by Editorial Office Director |
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2023-06-13 01:21 |
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Return for Revision |
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2023-06-13 01:21 |
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Revised |
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2023-07-18 16:39 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-08-14 02:57 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-08-15 09:04 |
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Articles in Press |
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2023-08-15 09:04 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-08-23 06:56 |
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Publish the Manuscript Online |
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2023-09-08 09:38 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Case Report |
| Article Title |
Efficacy of abatacept treatment in a patient with enteropathy carrying a variant of unsignificance in CTLA4 gene: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ugur Musabak, Tuba Erdoğan, Serdar Ceylaner, Emre Özbek, Nuretdin Suna and Binnaz Handan Özdemir |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Emre Özbek, MD, Doctor, Doctor, Department of Immunology-Allergy, Etlik City Hospital, Halil Sezai Erkut Street No:5 Yenimahalle/Etlik, Ankara 06490, Ankara, Türkiye. emreozbek55@yahoo.com.tr |
| Key Words |
Common variable immunodeficiency; Abatacept; CTLA4 antigen; Case report |
| Core Tip |
In this article, a 25-year-old female patient who applied to our outpatient clinic with the complaints of severe diarrhea and weight loss is presented. As a result of the clinical examination, laboratory tests and histopathological examinations, the patient was diagnosed with common variable immunodeficiency with severe enteropathy. Variants of uncertain significance were detected in 1 cytotoxic T lymphocyte antigen-4 (CTLA4) gene region and 2 lipopolysaccharide-responsive beige-like anchor gene regions in the patient who underwent Whole Exome Sequencing test. Although these polymorphisms have been listed as non-pathogenic in the variant database, their association with some autoimmune diseases had been shown in the literature before. CTLA-4-Ig fusion protein, which had been shown to be effective in these autoimmune diseases, was administered to our patient without delay and a dramatic improvement was achieved in clinical findings. |
| Publish Date |
2023-09-08 09:38 |
| Citation |
Musabak U, Erdoğan T, Ceylaner S, Özbek E, Suna N, Özdemir BH. Efficacy of abatacept treatment in a patient with enteropathy carrying a variant of unsignificance in CTLA4 gene: A case report. World J Clin Cases 2023; 11(26): 6176-6182
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| URL |
https://www.wjgnet.com/2307-8960/full/v11/i26/6176.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v11.i26.6176 |
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