Publication Name	World Journal of Translational Medicine
Manuscript ID	8534
Country	Brazil

Received	2014-01-03 11:15
Peer-Review Started	2014-01-03 18:15
To Make the First Decision	2014-02-13 15:56
Return for Revision	2014-02-17 19:31
Revised	2014-02-28 23:26
Second Decision	2014-03-14 18:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-03-14 18:38
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-12 15:06
Publish the Manuscript Online	2014-04-14 17:09

ISSN	2220-6132 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Review
Article Title	Neurological and behavioral manifestations of cerebral malaria: An update
Manuscript Source	Invited Manuscript
All Author List	Marta Chagas Monteiro, Fabio Rodrigues Oliveira, Gedeão Batista Oliveira, Pedro Roosevelt Torres Romão and Cristiane Socorro Ferraz Maia
Funding Agency and Grant Number
Corresponding Author	Cristiane Socorro Ferraz Maia, PhD, Program in Pharmaceutical Sciences, Faculty of Pharmacy, Laboratory of inflammation and behavior, Federal University of Pará/UFPA, Rua Augusto Correia SN, Guamá, Belém, PA 66075900, Brazil. crismaia@ufpa.br
Key Words	Malaria; Cerebral malaria; Neuropathology; Plasmodium sp; Plasmodium falciparum
Core Tip	This review attempts to compile the limited current knowledge on the behavioral and cognitive effects of cerebral malaria (CM) and the possible pathological mechanisms related to neurobehavioral manifestations. CM induces acute/chronic neurological damage, affecting several Central Nervous System regions responsible for behavioral, neurological and cognitive functions which may result in motor deficits, epilepsy, blindness, speech/hearing and memory/attention disorders, hyperactivity, anxiety-like behavior, neuropsychiatric manifestations of post malaria neurological syndrome, both in humans and animal models. The action mechanisms involved in the alterations are not yet clearly defined; however proinflammatory mediators have been described with consequent axonal damage and demyelination.
Publish Date	2014-04-14 17:09
Citation	Monteiro MC, Oliveira FR, Oliveira GB, Rom?o PRT, Maia CSF. Neurological and behavioral manifestations of cerebral malaria: An update. World J Transl Med 2014; 3(1): 9-16
URL	http://www.wjgnet.com/2220-6132/full/v3/i1/9.htm
DOI	http://dx.doi.org/10.5528/wjtm.v3.i1.9

Full Article (PDF)	WJTM-3-9.pdf
Full Article (Word)	WJTM-3-9.doc
Manuscript File	8534-Review.docx
Answering Reviewers	8534-Answering reviewers.pdf
Copyright License Agreement	8534-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8534-Language certificate.pdf
Peer-review Report	8534-Peer review(s).pdf
Scientific Editor Work List	8534-Scientific editor work list.doc