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Articles Published Processes
9/13/2023 12:15:07 PM | Browse: 254 | Download: 510
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Received |
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2023-04-24 19:16 |
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Peer-Review Started |
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2023-04-24 19:20 |
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To Make the First Decision |
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Return for Revision |
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2023-06-14 01:46 |
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Revised |
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2023-06-28 20:23 |
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Second Decision |
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2023-07-28 02:11 |
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Accepted by Journal Editor-in-Chief |
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2023-08-01 09:56 |
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Accepted by Executive Editor-in-Chief |
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2023-08-02 08:30 |
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Articles in Press |
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2023-08-02 08:30 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-09-07 06:48 |
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Publish the Manuscript Online |
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2023-09-13 12:15 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Hypothesis that alpha-amylase evokes regulatory mechanisms originating in the pancreas, gut and circulation, which govern glucose/insulin homeostasis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Stefan G Pierzynowski, Christine Stier and Kateryna Pierzynowska |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kateryna Pierzynowska, DSc, PhD, Researcher, Department of Biology, Lund University, Sölvegatan 35, Lund 22362, Sweden. katerina.goncharova@biol.lu.se |
| Key Words |
Pancreas; Alpha-amylase; Acini-islet-acinar axis; Hyperglycaemia; Bariatrics; Insulin; Incretins; Glucose-dependent insulinotropic polypeptide; Glucagon-like peptide-1; Exocrine pancreatic insufficiency; Pancreatic enzyme therapy; Diabetes |
| Core Tip |
The concept of the acini-islet-acinar axis postulates that insulin stimulates amylase synthesis and amylase in turn inhibits insulin production. This regulation is of particular significance with regards to postoperative glucose regulation after bariatric bypass surgery. The interaction of salivary amylase at the alimentary limb and pancreatic amylase, exclusively at the common channel, results in an immediate metabolic effect that leads to a significant reduction in incretin-induced hyperinsulinaemia and a marked improvement in glucose action on insulin production. As a result, both pancreatic beta cells and acinar cells are effectively protected against depletion. |
| Publish Date |
2023-09-13 12:15 |
| Citation |
Pierzynowski SG, Stier C, Pierzynowska K. Hypothesis that alpha-amylase evokes regulatory mechanisms originating in the pancreas, gut and circulation, which govern glucose/insulin homeostasis. World J Diabetes 2023; 14(9): 1341-1348 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i9/1341.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i9.1341 |
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