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Articles Published Processes
10/19/2023 4:26:38 PM | Browse: 289 | Download: 959
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Received |
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2023-06-05 17:26 |
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Peer-Review Started |
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2023-06-05 17:27 |
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To Make the First Decision |
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Return for Revision |
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2023-08-08 01:27 |
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Revised |
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2023-08-18 16:20 |
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Second Decision |
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2023-09-22 03:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-09-28 06:00 |
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Articles in Press |
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2023-09-28 06:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-10-10 23:46 |
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Publish the Manuscript Online |
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2023-10-19 16:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Observational Study |
| Article Title |
Risk assessment of venous thromboembolism in inflammatory bowel disease by inherited risk in a population-based incident cohort
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Andrew S Rifkin, Zhuqing Shi, Jun Wei, Siqun Lilly Zheng, Brian T Helfand, Jonathan S Cordova, Vincent F Biank, Alfonso J Tafur, Omar Khan and Jianfeng Xu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jianfeng Xu, MD, Professor, Program for Personalized Cancer Care, NorthShore University HealthSystem, 1001 University Place, Evanston, IL 60201, United States. jxu@northshore.org |
| Key Words |
Inflammatory bowel disease; Venous thromboembolism; Polygenic score; Factor V leiden; Prothrombin gene mutation |
| Core Tip |
Based on 8475 inflammatory bowel disease (IBD) patients from a population-based biobank, we showed they have an elevated risk for venous thromboembolism (VTE), with the overall proportion of incident VTE at 4.70%, similar to 4.66% observed in cancer patients. Polygenic score (PGS) is a significant predictor for VTE events, stronger than the well-known F5 factor V leiden mutation and F2 G20210A prothrombin gene mutation. The overall proportion of incident VTE is 8.53% in patients at the top 10 PGS percentile. These findings highlight the importance of VTE complications in IBD patients and provide genetic tools for personalized thromboprophylaxis. |
| Publish Date |
2023-10-19 16:26 |
| Citation |
Rifkin AS, Shi Z, Wei J, Zheng SL, Helfand BT, Cordova JS, Biank VF, Tafur AJ, Khan O, Xu J. Risk assessment of venous thromboembolism in inflammatory bowel disease by inherited risk in a population-based incident cohort. World J Gastroenterol 2023; 29(39): 5494-5502 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i39/5494.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i39.5494 |
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