Publication Name	World Journal of Transplantation
Manuscript ID	86632
Country	Brazil

Received	2023-06-28 12:22
Peer-Review Started	2023-06-28 12:24
To Make the First Decision
Return for Revision	2023-07-19 09:01
Revised	2023-07-31 22:39
Second Decision	2023-08-11 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-08-11 08:28
Articles in Press	2023-08-11 08:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-09-11 09:56
Publish the Manuscript Online	2023-09-15 04:42

ISSN	2220-3230 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Minireviews
Article Title	Impact of tacrolimus intra-patient variability in adverse outcomes after organ transplantation
Manuscript Source	Invited Manuscript
All Author List	Maria Clara Morais, Maria Eduarda Soares, Gabriela Costa, Laura Guerra, Nayana Vaz, Liana Codes and Paulo Lisboa Bittencourt
ORCID	Author(s) ORCID Number Maria Clara Morais http://orcid.org/0000-0003-3752-584X Maria Eduarda Soares http://orcid.org/0009-0009-3762-8161 Gabriela Costa http://orcid.org/0009-0009-3041-8436 Laura Guerra http://orcid.org/0009-0000-4145-9019 Nayana Vaz http://orcid.org/0000-0002-6766-0164 Liana Codes http://orcid.org/0000-0001-5178-8705 Paulo Lisboa Bittencourt http://orcid.org/0000-0003-0883-4870
Funding Agency and Grant Number
Corresponding Author	Paulo Lisboa Bittencourt, MD, PhD, Chief Doctor, Unit of Gastroenterology and Hepatology, Portuguese Hospital, 914 Av. Princesa Isabel, Barra, Salvador 40130-030, Bahia, Brazil. plbbr@uol.com.br
Key Words	Tacrolimus; Intra-patient variability; Rejection; Organ transplantation; Graft survival; Outcomes
Core Tip	Tacrolimus is widely used after solid organ transplantation. High intra-patient variability of tacrolimus (Tac IPV) has been associated with poor graft and patient survival. This review summarizes current evidence regarding the impact of high Tac IPV in several outcomes after kidney, liver, heart, lung and pancreas transplantation.
Publish Date	2023-09-15 04:42
Citation	Morais MC, Soares ME, Costa G, Guerra L, Vaz N, Codes L, Bittencourt PL. Impact of tacrolimus intra-patient variability in adverse outcomes after organ transplantation. World J Transplant 2023; 13(5): 254-263
URL	https://www.wjgnet.com/2220-3230/full/v13/i5/254.htm
DOI	https://dx.doi.org/10.5500/wjt.v13.i5.254

Full Article (PDF)	WJT-13-254-with-cover.pdf
Full Article (Word)	WJT-13-254.docx
Manuscript File	86632_Auto_Edited-JLW.docx
Answering Reviewers	86632-Answering reviewers.pdf
Audio Core Tip	86632-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	86632-Conflict-of-interest statement.pdf
Copyright License Agreement	86632-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	86632-Language certificate.pdf
Peer-review Report	86632-Peer-review(s).pdf
Scientific Misconduct Check	86632-Bing-Chen YL-2.png
Scientific Editor Work List	86632-Scientific editor work list.pdf
CrossCheck Report	86632-CrossCheck report.pdf