| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Case Control Study |
| Article Title |
Altered expression of miR-125a and dysregulated cytokines in systemic lupus erythematosus: Unveiling diagnostic and prognostic markers
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Tagreed Qassim Alsbihawi, Mojtaba Zare Ebrahimabad, Fakhri Sadat Seyedhosseini, Homa Davoodi, Nafiseh Abdolahi, Alireza Nazari, Saeed Mohammadi and Yaghoub Yazdani |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Golestan University of Medical Sciences |
113017 |
|
| Corresponding Author |
Saeed Mohammadi, PhD, Assistant Professor, Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, R9Q4+242, Gorgan 49341-74515, Iran. s.mohammadi@goums.ac.ir |
| Key Words |
Systemic lupus erythematosus; microRNA-125a; Interleukin-12; Tumor necrosis factor alpha; Biomarker |
| Core Tip |
The aim of this study was to investigate the levels of microRNA-125a (miR-125a), interleukin 12 (IL-12), and tumor necrosis factor-alpha (TNF-α) in the plasma of systemic lupus erythematosus (SLE) patients, and assess the diagnostic and prognostic value of these biomarkers in SLE. The study included healthy individuals, newly diagnosed SLE patients, and SLE patients undergoing treatment. The results revealed decreased levels of miR-125a in SLE patients, particularly in newly diagnosed cases. On the other hand, elevated levels of IL-12 and TNF-α were observed in SLE patients, especially in the early stages of the disease. The study also identified miR-125a, TNF-α, and IL-12 as potential diagnostic biomarkers for SLE. The negative correlation observed between miR-125a and IL-12/TNF-α suggests an interaction between these factors. These findings provide insights into new diagnostic and prognostic markers for SLE, highlighting the importance of immune dysregulation in the disease. |
| Publish Date |
2023-12-19 06:07 |
| Citation |
Alsbihawi TQ, Zare Ebrahimabad M, Seyedhosseini FS, Davoodi H, Abdolahi N, Nazari A, Mohammadi S, Yazdani Y. Altered expression of miR-125a and dysregulated cytokines in systemic lupus erythematosus: Unveiling diagnostic and prognostic markers. World J Exp Med 2023; 13(5): 102-114 |
| URL |
https://www.wjgnet.com/2220-315x/full/v13/i5/102.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v13.i5.102 |
