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Articles Published Processes
9/25/2023 9:07:43 AM | Browse: 181 | Download: 506
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Received |
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2023-07-19 18:50 |
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Peer-Review Started |
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2023-07-19 18:53 |
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To Make the First Decision |
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Return for Revision |
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2023-08-05 12:31 |
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Revised |
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2023-08-10 13:36 |
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Second Decision |
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2023-09-14 02:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-09-14 08:33 |
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Articles in Press |
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2023-09-14 08:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-09-01 09:31 |
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Typeset the Manuscript |
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2023-09-19 08:44 |
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Publish the Manuscript Online |
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2023-09-25 09:07 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vasiliy Ivanovich Reshetnyak and Igor Veniaminovich Maev |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Vasiliy Ivanovich Reshetnyak, DSc, MD, PhD, Full Professor, Department of Propaedeutics of Internal Diseases and Gastroenterology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, No. 20 Delegatskaya St., Build. 1, Moscow 127473, Russia. vasiliy.reshetnyak@yandex.ru |
| Key Words |
Primary biliary cholangitis; Antimitochondrial autoantibodies; MicroRNA 506; Inositol-1,4,5-trisphosphate receptor type 3; chloride/bicarbonate anion exchanger 2; Biliary bicarbonate umbrella; Dihydrolipoyl transacetylase (E2 subunit); Pyruvate dehydrogenase complex |
| Core Tip |
This review considers the mechanisms contributing to the damage of the E2 subunit of the pyruvate dehydrogenase complex, formation of antimitochondrial autoantibodies (AMAs), and the development of ductulopenia in primary biliary cholangitis asymptomatic stage. A hypothesis explaining the pathogenesis of the initial morphological (ductulopenia), immunologic (AMAs), and clinical (weakness, malaise, rapid fatigue) signs of the disease in the asymptomatic stage is proposed. |
| Publish Date |
2023-09-25 09:07 |
| Citation |
Reshetnyak VI, Maev IV. New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage. World J Gastroenterol 2023; 29(37): 5292-5304 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i37/5292.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i37.5292 |
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