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Articles Published Processes
10/1/2014 8:25:00 PM | Browse: 1465 | Download: 962
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Received |
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2014-01-08 18:24 |
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Peer-Review Started |
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2014-01-09 09:41 |
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To Make the First Decision |
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2014-02-14 17:46 |
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Return for Revision |
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2014-02-18 21:11 |
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Revised |
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Second Decision |
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2014-05-05 09:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-05-05 10:00 |
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Articles in Press |
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2014-05-23 09:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-09-18 15:27 |
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Publish the Manuscript Online |
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2014-10-01 20:25 |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Autobiography |
Article Title |
Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation
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Manuscript Source |
Invited Manuscript |
All Author List |
Devanshi Seth, Alastair Duly, Paul C Kuo, Geoffrey W McCaughan and Paul S Haber |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Philanthropic Anonymous Source |
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University of Sydney Bridging Support Grant, in part for Honours Project |
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National Health and Medical Research Council |
NHMRC |
Practitioner Research Fellowship for PH support |
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Corresponding Author |
Devanshi Seth, Principal Scientist, Drug Health Services, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia. d.seth@sydney.edu.au |
Key Words |
Hepatic stellate cells; Liver cirrhosis; Plasmin; Steatosis; Fibrogenesis; Transforming growth factor b; Osteopontin isoform |
Core Tip |
The present study confirms a novel hy?pothesis that alcohol induced plasmin is mediated via Osteopontin (OPN) in hepatic stellate cell (HSC). We show that OPN has a key role in alcohol-induced HSC functions such as signalling, cell migration and activation of fibrinolysis, extracellular matrix and fibrogenic pathways. Identification of transcriptional isoform OPN-C in patients with alcoholic cirrhosis and LX2, and proteolytically cleaved cOPN in mice with a single dose of alcohol is novel. Importantly, we have defined novel mechanisms of OPN action in alcohol-induced liver injury that have a broader significance in other forms of liver injury. |
Publish Date |
2014-10-01 20:25 |
Citation |
Seth D, Duly A, Kuo PC, McCaughan GW, Haber PS. Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation. World J Gastroenterol 2014; 20(36): 13088-13104 |
URL |
http://www.wjgnet.com/1007-9327/full/v20/i36/13088.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v20.i36.13088 |
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