BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
10/1/2014 8:25:00 PM | Browse: 1372 | Download: 803
Publication Name World Journal of Gastroenterology
Manuscript ID 8716
Country/Territory Australia
Received
2014-01-08 18:24
Peer-Review Started
2014-01-09 09:41
To Make the First Decision
2014-02-14 17:46
Return for Revision
2014-02-18 21:11
Revised
Second Decision
2014-05-05 09:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-05 10:00
Articles in Press
2014-05-23 09:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-09-18 15:27
Publish the Manuscript Online
2014-10-01 20:25
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation
Manuscript Source Invited Manuscript
All Author List Devanshi Seth, Alastair Duly, Paul C Kuo, Geoffrey W McCaughan and Paul S Haber
Funding Agency and Grant Number
Funding Agency Grant Number
Philanthropic Anonymous Source
University of Sydney Bridging Support Grant, in part for Honours Project
National Health and Medical Research Council NHMRC
Practitioner Research Fellowship for PH support
Corresponding Author Devanshi Seth, Principal Scientist, Drug Health Services, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia. d.seth@sydney.edu.au
Key Words Hepatic stellate cells; Liver cirrhosis; Plasmin; Steatosis; Fibrogenesis; Transforming growth factor b; Osteopontin isoform
Core Tip The present study confirms a novel hy?pothesis that alcohol induced plasmin is mediated via Osteopontin (OPN) in hepatic stellate cell (HSC). We show that OPN has a key role in alcohol-induced HSC functions such as signalling, cell migration and activation of fibrinolysis, extracellular matrix and fibrogenic pathways. Identification of transcriptional isoform OPN-C in patients with alcoholic cirrhosis and LX2, and proteolytically cleaved cOPN in mice with a single dose of alcohol is novel. Importantly, we have defined novel mechanisms of OPN action in alcohol-induced liver injury that have a broader significance in other forms of liver injury.
Publish Date 2014-10-01 20:25
Citation Seth D, Duly A, Kuo PC, McCaughan GW, Haber PS. Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation. World J Gastroenterol 2014; 20(36): 13088-13104
URL http://www.wjgnet.com/1007-9327/full/v20/i36/13088.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i36.13088
Full Article (PDF) WJG-20-13088.pdf
Full Article (Word) WJG-20-13088.doc
Manuscript File 8716-Review.docx
Answering Reviewers 8716-Answering reviewers.pdf
Copyright License Agreement 8716-Copyright asignment.pdf
Institutional Review Board Approval Form or Document Ethics_Committee_20140103125035.pdf
Peer-review Report 8716-Peer review.pdf
Scientific Editor Work List 8716-Scientific editor work list.pdf