Publication Name	World Journal of Gastroenterology
Manuscript ID	8716
Country	Australia

Received	2014-01-08 18:24
Peer-Review Started	2014-01-09 09:41
First Decision by Editorial Office Director
Return for Revision	2014-02-18 21:11
Revised
Publication Fee Transferred
Second Decision by Editor	2014-05-05 09:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-05-05 10:00
Articles in Press	2014-05-23 09:42
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-18 15:27
Publish the Manuscript Online	2014-10-01 20:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation
Manuscript Source	Invited Manuscript
All Author List	Devanshi Seth, Alastair Duly, Paul C Kuo, Geoffrey W McCaughan and Paul S Haber
Funding Agency and Grant Number	Funding Agency Grant Number Philanthropic Anonymous Source University of Sydney Bridging Support Grant, in part for Honours Project National Health and Medical Research Council NHMRC Practitioner Research Fellowship for PH support
Corresponding Author	Devanshi Seth, Principal Scientist, Drug Health Services, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia. d.seth@sydney.edu.au
Key Words	Hepatic stellate cells; Liver cirrhosis; Plasmin; Steatosis; Fibrogenesis; Transforming growth factor b; Osteopontin isoform
Core Tip	The present study confirms a novel hy?pothesis that alcohol induced plasmin is mediated via Osteopontin (OPN) in hepatic stellate cell (HSC). We show that OPN has a key role in alcohol-induced HSC functions such as signalling, cell migration and activation of fibrinolysis, extracellular matrix and fibrogenic pathways. Identification of transcriptional isoform OPN-C in patients with alcoholic cirrhosis and LX2, and proteolytically cleaved cOPN in mice with a single dose of alcohol is novel. Importantly, we have defined novel mechanisms of OPN action in alcohol-induced liver injury that have a broader significance in other forms of liver injury.
Publish Date	2014-10-01 20:25
Citation	Seth D, Duly A, Kuo PC, McCaughan GW, Haber PS. Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation. World J Gastroenterol 2014; 20(36): 13088-13104
URL	http://www.wjgnet.com/1007-9327/full/v20/i36/13088.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i36.13088

Full Article (PDF)	WJG-20-13088.pdf
Full Article (Word)	WJG-20-13088.doc
Manuscript File	8716-Review.docx
Answering Reviewers	8716-Answering reviewers.pdf
Copyright License Agreement	8716-Copyright asignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140103125035.pdf
Peer-review Report	8716-Peer review.pdf
Scientific Editor Work List	8716-Scientific editor work list.pdf