Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	8746
Country	Japan

Received	2014-01-05 11:47
Peer-Review Started	2014-01-05 14:17
To Make the First Decision	2014-02-27 09:31
Return for Revision	2014-03-06 10:54
Revised	2014-04-02 11:32
Second Decision	2014-05-29 09:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-29 09:54
Articles in Press	2014-05-29 10:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-10 15:25
Publish the Manuscript Online	2014-06-16 15:27

ISSN	1948-5190 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Monitoring salivary amylase activity is useful for providing timely analgesia under sedation
Manuscript Source	Unsolicited Manuscript
All Author List	Masaya Uesato, Yoshihiro Nabeya, Takashi Akai, Masahito Inoue, Yoshiyuki Watanabe, Daisuke Horibe, Hiroshi Kawahira, Hideki Hayashi and Hisahiro Matsubara
Funding Agency and Grant Number	Funding Agency Grant Number Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, Japan C: #23591018
Corresponding Author	Masaya Uesato, MD, Department of Frontier Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670, Japan. uesato@faculty.chiba-u.jp
Key Words	Salivary amylase activity; Endoscopic submucosal dissection; Analgesia; Anesthesia; Sedation; Sympathetic excitement; Gastric wall tension
Core Tip	The analgesia in patients during endoscopic submucosal dissection (ESD) under deep sedation (DS) has not yet been developed. There was no way of measuring the degree of the pain in those patients. This study revealed that the salivary amylase activity (sAMY) shown as sympathetic excitement (SE) sometimes was elevated during ESD without any change in circulatory dynamics or consciousness. We suggest that sAMY is elevated when patients feel pain during ESD under DS. By detecting twice the actual sAMY based on the preoperative level, the release of gastric wall tension or the administration of analgesic agents should be considered.
Publish Date	2014-06-16 15:27
Citation	Uesato M, Nabeya Y, Akai T, Inoue M, Watanabe Y, Horibe D, Kawahira H, Hayashi H, Matsubara H. Monitoring salivary amylase activity is useful for providing timely analgesia under sedation. World J Gastrointest Endosc 2014; 6(6): 240-247
URL	http://www.wjgnet.com/1948-5190/full/v6/i6/240.htm
DOI	http://dx.doi.org/10.4253/wjge.v6.i6.240

Full Article (PDF)	WJGE-6-240.pdf
Manuscript File	8746-Review.docx
Answering Reviewers	8746-Answering reviewers.pdf
Copyright License Agreement	8746-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8746-Language certificate.pdf
Peer-review Report	8746-Peer review(s).pdf
Scientific Misconduct Check	8746-CrossCheck.jpg
Scientific Editor Work List	8746-Scientific editor work list.pdf