Publication Name	World Journal of Gastroenterology
Manuscript ID	88022
Country	China

Received	2023-09-06 08:04
Peer-Review Started	2023-09-06 08:07
To Make the First Decision
Return for Revision	2023-11-01 04:31
Revised	2023-11-04 10:09
Second Decision	2023-11-23 03:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-12-04 06:07
Articles in Press	2023-12-04 06:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-12-15 02:13
Publish the Manuscript Online	2023-12-19 02:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	5-methoxytryptophan induced apoptosis and PI3K/Akt/FoxO3a phosphorylation in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Tian-Lei Zhao, Yue Qi, Yi-Fan Wang, Yi Wang, Hui Liang and Ya-Bin Pu
ORCID	Author(s) ORCID Number Hui Liang http://orcid.org/0009-0003-7797-7573 Ya-Bin Pu http://orcid.org/0009-0007-1668-9462
Funding Agency and Grant Number
Corresponding Author	Ya-Bin Pu, MMed, Associate Chief Physician, Department of General Surgery, Naval Medical Center of PLA, No. 338 Huaihai Road, Changning District, Shanghai 200052, China. yabinpu26@163.com
Key Words	Colorectal cancer; 5-methoxytryptophan; Apoptosis; Cell cycle arrest; PI3K/Akt signaling pathway
Core Tip	Colorectal cancer (CRC) is insensitive to radiotherapy and has poor therapeutic efficacy, and there is an urgent need to find new therapeutic targets to prolong patient survival. 5-methoxytryptophan (5-MTP) is a tryptophan metabolite present in both animals and humans. 5-MTP has a wide range of physiological functions such as stabilizing endothelial function, anti-inflammation, and antioxidant to prevent cellular damage. Our study found that 5-MTP combined with an inhibitor of the PI3K/Akt/FoxO3a signaling pathway significantly promoted apoptosis and cell cycle arrest and inhibited cell proliferation in CRC cells compared with 5-MTP alone.
Publish Date	2023-12-19 02:09
Citation	Zhao TL, Qi Y, Wang YF, Wang Y, Liang H, Pu YB. 5-methoxytryptophan induced apoptosis and PI3K/Akt/FoxO3a phosphorylation in colorectal cancer. World J Gastroenterol 2023; 29(47): 6148-6160
URL	https://www.wjgnet.com/1007-9327/full/v29/i47/6148.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i47.6148

Full Article (PDF)	WJG-29-6148-with-cover.pdf
Full Article (Word)	WJG-29-6148.docx
Manuscript File	88022_Auto_Edited-JLW.docx
Answering Reviewers	88022-Answering reviewers.pdf
Audio Core Tip	88022-Audio core tip.mp3
Biostatistics Review Certificate	88022-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	88022-Conflict-of-interest statement.pdf
Copyright License Agreement	88022-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	88022-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	88022-Language certificate.pdf
Peer-review Report	88022-Peer-review(s).pdf
Scientific Misconduct Check	88022-Bing-Wang JJ-2.png
Scientific Editor Work List	88022-Scientific editor work list.pdf