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Articles Published Processes
12/19/2023 2:09:20 AM | Browse: 277 | Download: 751
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Received |
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2023-09-06 08:04 |
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Peer-Review Started |
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2023-09-06 08:07 |
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First Decision by Editorial Office Director |
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2023-11-01 04:31 |
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Return for Revision |
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2023-11-01 04:31 |
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Revised |
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2023-11-04 10:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-11-23 03:56 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-12-04 06:07 |
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Articles in Press |
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2023-12-04 06:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-12-15 02:13 |
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Publish the Manuscript Online |
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2023-12-19 02:09 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
5-methoxytryptophan induced apoptosis and PI3K/Akt/FoxO3a phosphorylation in colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tian-Lei Zhao, Yue Qi, Yi-Fan Wang, Yi Wang, Hui Liang and Ya-Bin Pu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ya-Bin Pu, MMed, Associate Chief Physician, Department of General Surgery, Naval Medical Center of PLA, No. 338 Huaihai Road, Changning District, Shanghai 200052, China. yabinpu26@163.com |
| Key Words |
Colorectal cancer; 5-methoxytryptophan; Apoptosis; Cell cycle arrest; PI3K/Akt signaling pathway |
| Core Tip |
Colorectal cancer (CRC) is insensitive to radiotherapy and has poor therapeutic efficacy, and there is an urgent need to find new therapeutic targets to prolong patient survival. 5-methoxytryptophan (5-MTP) is a tryptophan metabolite present in both animals and humans. 5-MTP has a wide range of physiological functions such as stabilizing endothelial function, anti-inflammation, and antioxidant to prevent cellular damage. Our study found that 5-MTP combined with an inhibitor of the PI3K/Akt/FoxO3a signaling pathway significantly promoted apoptosis and cell cycle arrest and inhibited cell proliferation in CRC cells compared with 5-MTP alone. |
| Publish Date |
2023-12-19 02:09 |
| Citation |
Zhao TL, Qi Y, Wang YF, Wang Y, Liang H, Pu YB. 5-methoxytryptophan induced apoptosis and PI3K/Akt/FoxO3a phosphorylation in colorectal cancer. World J Gastroenterol 2023; 29(47): 6148-6160
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| URL |
https://www.wjgnet.com/1007-9327/full/v29/i47/6148.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i47.6148 |
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