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Articles Published Processes
3/12/2024 10:04:16 AM | Browse: 245 | Download: 864
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Received |
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2023-10-10 16:00 |
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Peer-Review Started |
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2023-10-10 16:03 |
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First Decision by Editorial Office Director |
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2023-12-06 06:01 |
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Return for Revision |
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2023-12-07 09:19 |
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Revised |
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2023-12-31 15:27 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-02-01 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-02-01 06:27 |
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Articles in Press |
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2024-02-01 06:27 |
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Edit the Manuscript by Language Editor |
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2024-01-30 17:56 |
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Typeset the Manuscript |
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2024-03-04 06:15 |
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Publish the Manuscript Online |
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2024-03-12 10:04 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Chinese herbal medicine decreases incidence of hepatocellular carcinoma in diabetes mellitus patients with regular insulin management
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hsiang-Chun Lai, Ju-Chien Cheng, Hei-Tung Yip, Long-Bin Jeng and Sheng-Teng Huang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Science and Technology Council of Taiwan |
NSC112-2320-B-039-045- |
| Department of Chinese Medicine and Pharmacy and Ministry of Health and Welfare |
MOHW-112-CMC-03 |
| China Medical University Hospital |
DMR-111-013 |
| China Medical University Hospital |
DMR-111-195 |
| China Medical University Hospital |
DMR-112-004 |
| China Medical University Hospital |
DMR-112-177 |
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| Corresponding Author |
Sheng-Teng Huang, MD, PhD, Doctor, Doctor, Professor, Department of Chinese Medicine, China Medical University Hospital; School of Chinese Medicine, China Medical University, No. 2 Yude Road, North District, Taichung 40447, Taiwan. sheng.teng@yahoo.com |
| Key Words |
Hepatocellular carcinoma; Diabetes mellitus; Insulin; Herb; Taiwanese National health insurance research database |
| Core Tip |
Type 2 diabetes mellitus (DM) is an independent risk factor for hepatocellular carcinoma (HCC), while insulin is a potent mitogen. In this propensity-score-matched population-based cohort study, we investigated whether regular herbal medicine use can decrease HCC risk in DM patients with regular insulin control. DM patients with regular herb use had a 12% decreased risk of HCC compared to the control group. The cohort with herb use of > 5 years cumulatively exhibited a protective effect against development of HCC. Moreover, among patients who developed HCC, herb users exhibited a longer survival time than non-users (adjusted hazard ratio = 0.78). |
| Publish Date |
2024-03-12 10:04 |
| Citation |
Lai HC, Cheng JC, Yip HT, Jeng LB, Huang ST. Chinese herbal medicine decreases incidence of hepatocellular carcinoma in diabetes mellitus patients with regular insulin management. World J Gastrointest Oncol 2024; 16(3): 716-731 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i3/716.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i3.716 |
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