Publication Name	World Journal of Clinical Oncology
Manuscript ID	8897
Country	Japan

Received	2014-01-11 13:48
Peer-Review Started	2014-01-11 15:35
To Make the First Decision	2014-03-12 16:47
Return for Revision	2014-03-20 20:26
Revised	2014-03-31 10:01
Second Decision	2014-07-29 08:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-29 09:05
Articles in Press	2014-07-29 09:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-19 13:33
Publish the Manuscript Online	2014-12-11 14:23

ISSN	2218-4333 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Topic Highlights
Article Title	Breast cancer phenotypes regulated by tissue factor-factor VII pathway: Possible therapeutic targets
Manuscript Source	Invited Manuscript
All Author List	Shiro Koizume and Yohei Miyagi
Funding Agency and Grant Number
Corresponding Author	Dr. Shiro Koizume, Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 2-3-2 Nakao Asahi-ku, Yokohama 241-0815, Japan. skoizume@gancen.asahi.yokohama.jp
Key Words	Breast cancer; Blood coagulation; Tissue factor; Coagulation factor VII; Gene regulation; Therapeutic strategy
Core Tip	Breast cancer is a worldwide problem. Difficulties with treating the disease and its recurrence persist due, in part, to a lack of therapeutic molecular targets. Blood coagulation factor VII (fVII) is generally produced in the liver. Tissue factor (TF), the cellular receptor for fVII, is an integral membrane protein that plays key roles in the extrinsic coagulation cascade. Formation of the TF-fVII complex causes contributes to the malignant phenotype of breast cancer cells. In this review, we summarize the breast cancer biology associated with the TF-fVII pathway. Further, we will discuss how these mechanisms can be targeted as therapeutics for this aggressive disease.
Publish Date	2014-12-11 14:23
Citation	Koizume S, Miyagi Y. Breast cancer phenotypes regulated by tissue factor-factor VII pathway: Possible therapeutic targets. World J Clin Oncol 2014; 5(5): 908-920
URL	http://www.wjgnet.com/2218-4333/full/v5/i5/908.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i5.908

Full Article (PDF)	WJCO-5-908.pdf
Full Article (Word)	WJCO-5-908.doc
Manuscript File	8897-Review.docx
Answering Reviewers	8897-Answering reviewers.pdf
Copyright License Agreement	8897-Copyright assignment.pdf
Peer-review Report	8897-Peer review(s).pdf
Scientific Misconduct Check	8897-CrossCheck.jpg
Scientific Editor Work List	8897-Scientific editor work list.pdf