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Articles Published Processes
2/26/2024 4:10:20 AM | Browse: 128 | Download: 520
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Received |
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2023-10-18 09:36 |
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Peer-Review Started |
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2023-10-18 09:37 |
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To Make the First Decision |
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Return for Revision |
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2023-12-02 16:22 |
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Revised |
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2023-12-14 08:07 |
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Second Decision |
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2023-12-26 03:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-01-12 07:09 |
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Articles in Press |
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2024-01-12 07:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2024-02-02 15:23 |
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Typeset the Manuscript |
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2024-02-19 01:46 |
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Publish the Manuscript Online |
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2024-02-26 04:10 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Basic Study |
| Article Title |
Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan Ren, Yan-Ni Cui and Hong-Wei Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Department of Shanxi Province |
YDZJSX2021B009 |
| Health Commission of Shanxi Province |
2021XM07 |
| Shanxi Provincial Department of Education |
2023KY380 |
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| Corresponding Author |
Hong-Wei Wang, PhD, Professor, Department of Hematology, The Second Hospital of Shanxi Medical University, No. 382 Wuyi Road, Taiyuan 030001, Shanxi Province, China. wanghw68@hotmail.com |
| Key Words |
Hematopoietic stem cells; Nicotinamide; Concentration; Proliferation; Differentiation; Sirtuin 1 |
| Core Tip |
This study reveals the dominant subgroups of hematopoietic stem cells (HSCs) and molecular mechanisms underlying the effects of different nicotinamide (NAM) concentrations. Activation or inhibition of sirtuin 1 (SIRT1) is determined by the concentration of NAM. High concentrations inhibit SIRT1 but are not conducive to self-renewal of HSCs, whereas low concentrations balance HSC proliferation and differentiation by regulating the SIRT1-HIF1A pathway and reactive oxygen species production, effectively promoting in vitro expansion of the stem cells. These findings could allow adjustment of NAM concentrations according to expansion needs and may help predict small molecules that synergistically promote expansion with NAM. |
| Publish Date |
2024-02-26 04:10 |
| Citation |
Ren Y, Cui YN, Wang HW. Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro. World J Stem Cells 2024; 16(2): 163-175 |
| URL |
https://www.wjgnet.com/1948-0210/full/v16/i2/163.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v16.i2.163 |
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