| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Observational Study |
| Article Title |
Inverse relationship between platelet Akt activity and hippocampal atrophy: A pilot case-control study in patients with diabetes mellitus
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Haruhiko Tokuda, Takamitsu Hori, Daisuke Mizutani, Tomoyuki Hioki, Kumi Kojima, Takashi Onuma, Yukiko Enomoto, Tomoaki Doi, Rie Matsushima-Nishiwaki, Shinji Ogura, Hiroki Iida, Toru Iwama, Takashi Sakurai and Osamu Kozawa |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Research Funding for Longevity Science from The National Center for Geriatrics and Gerontology, Japan |
19-21 |
| Research Funding for Longevity Science from The National Center for Geriatrics and Gerontology, Japan |
22-19 |
|
| Corresponding Author |
Haruhiko Tokuda, MD, PhD, Professor, Department of Metabolic Research, Research Institute, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Japan. tokuda@ncgg.go.jp |
| Key Words |
Akt; Platelet; Hippocampal atrophy; Magnetic resonance imaging; Diabetes mellitus |
| Core Tip |
Type 2 diabetes mellitus (T2DM) is caused by insulin resistance, and Akt is involved in this process. Akt also plays an important role in human platelet activation. The hippocampus, associated with memory and learning, can decrease in volume in patients with an insulin-resistant phenotype. We investigated the relationship between Akt phosphorylation in unstimulated platelets and hippocampal volume-reflecting Z-score in T2DM patients. The levels of phosphorylated Akt corrected for phosphorylated p38 mitogen-activated protein kinase were inversely correlated with Z-scores in T2DM patients. These results suggest an inverse relationship between Akt activation in platelets and hippocampal atrophy in patients with T2DM. |
| Publish Date |
2024-01-11 05:28 |
| Citation |
Tokuda H, Hori T, Mizutani D, Hioki T, Kojima K, Onuma T, Enomoto Y, Doi T, Matsushima-Nishiwaki R, Ogura S, Iida H, Iwama T, Sakurai T, Kozawa O. Inverse relationship between platelet Akt activity and hippocampal atrophy: A pilot case-control study in patients with diabetes mellitus. World J Clin Cases 2023; 12(2): 302-313 |
| URL |
https://www.wjgnet.com/2307-8960/full/v12/i2/302.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v12.i2.302 |
