Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	89227
Country	Spain

Received	2023-10-26 21:14
Peer-Review Started	2023-10-26 21:15
To Make the First Decision
Return for Revision	2023-12-02 16:06
Revised	2023-12-14 23:27
Second Decision	2024-01-10 02:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-01-10 05:18
Articles in Press	2024-01-10 05:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-27 05:03
Publish the Manuscript Online	2024-02-02 09:42

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Observational Study
Article Title	Systemic inflammation response index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial
Manuscript Source	Invited Manuscript
All Author List	Vilma Pacheco-Barcia, Sara Custodio-Cabello, Fatima Carrasco-Valero, Magda Palka-Kotlowska, Axel Mariño-Mendez, Alberto Carmona-Bayonas, Javier Gallego, A J Muñoz Martín, Paula Jimenez-Fonseca and Luis Cabezon-Gutierrez
ORCID	Author(s) ORCID Number Vilma Pacheco-Barcia http://orcid.org/0000-0003-0141-1306 Sara Custodio-Cabello http://orcid.org/0000-0001-8710-2592 Fatima Carrasco-Valero http://orcid.org/0009-0000-2597-9225 Magda Palka-Kotlowska http://orcid.org/0000-0001-6550-2540 Axel Mariño-Mendez http://orcid.org/0009-0007-9668-3983 Alberto Carmona-Bayonas http://orcid.org/0000-0002-1930-9660 Javier Gallego http://orcid.org/0000-0002-0584-1242 A J Muñoz Martín http://orcid.org/0000-0001-6977-8249 Paula Jimenez-Fonseca http://orcid.org/0000-0003-4592-3813 Luis Cabezon-Gutierrez http://orcid.org/0000-0002-3468-3626
Funding Agency and Grant Number
Corresponding Author	Vilma Pacheco-Barcia, MD, MSc, PhD, Doctor, Department of Medical Oncology, Hospital Universitario de Torrejon, C/Mateo Inurria S/N, Madrid 28850, Spain. vepacheco@torrejonsalud.com
Key Words	Pancreatic cancer; Nutrition; Prognostic factor; Inflammation; Advanced cancer; Systemic inflammatory response index; Weight loss
Core Tip	Advancements in the therapeutic landscape for pancreatic cancer have been modest in the recent years and the prognostic potential of the systemic inflammation response index (SIRI) in advanced pancreatic cancer has garnered interest. Originating from the PANTHEIA-Spanish Society of Medical Oncology (SEOM) initiative, a multicentric, observational, study promoted by the SEOM Real World-Evidence work group, our pilot research seeks to bridge this knowledge gap. Specifically, we focused on the interplay between weight loss and the inflammatory state as demarcated by SIRI. A significant correlation between elevated SIRI levels and decreased survival in patients with metastatic pancreatic cancer, with a notable association with weight loss, was observed.
Publish Date	2024-02-02 09:42
Citation	Pacheco-Barcia V, Custodio-Cabello S, Carrasco-Valero F, Palka-Kotlowska M, Mariño-Mendez A, Carmona-Bayonas A, Gallego J, Martín AJM, Jimenez-Fonseca P, Cabezon-Gutierrez L. Systemic inflammation response index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial. World J Gastrointest Oncol 2024; 16(2): 386-397
URL	https://www.wjgnet.com/1948-5204/full/v16/i2/386.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i2.386

Full Article (PDF)	WJGO-16-386-with-cover.pdf
Full Article (Word)	WJGO-16-386.docx
STROBE Statement	89227-STROBE statement.pdf
Manuscript File	89227_Auto_Edited-YJP.docx
Answering Reviewers	89227-Answering reviewers.pdf
Audio Core Tip	89227-Audio core tip.mp3
Biostatistics Review Certificate	89227-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89227-Conflict-of-interest statement.pdf
Copyright License Agreement	89227-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	89227-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	89227-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	89227-Language certificate.pdf
Peer-review Report	89227-Peer-review(s).pdf
Scientific Misconduct Check	89227-Bing-Wang JJ-2.png
Scientific Editor Work List	89227-Scientific editor work list.pdf