BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/25/2014 4:06:00 PM | Browse: 811 | Download: 903
Publication Name World Journal of Gastroenterology
Manuscript ID 8927
Country/Territory China
Received
2014-01-13 10:54
Peer-Review Started
2014-01-23 08:53
To Make the First Decision
2014-02-14 13:51
Return for Revision
2014-02-20 10:29
Revised
2014-03-19 08:52
Second Decision
2014-04-23 09:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-04-23 10:21
Articles in Press
2014-05-23 09:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-05-14 15:32
Typeset the Manuscript
2014-07-10 09:07
Publish the Manuscript Online
2014-07-26 13:36
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice
Manuscript Source Unsolicited Manuscript
All Author List Guo-Qiang Xu, Cheng-Fu Xu, Hong-Tan Chen, Shan Liu, Xiao-Dong Teng, Gen-Yun Xu and Chao-Hui Yu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81070366
Corresponding Author Guo-Qiang Xu, MD, Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zyxgq@sina.cn
Key Words Cholesterol gallstone disease; Caveolin-3; Cholecystokinin A receptor; Lithogenic diet; Mechanism
Core Tip Cholesterol gallstone disease (CGD) is one of the most common digestive diseases worldwide, while the mechanisms of this disease are not fully understood. In this study, we established a mouse model of CGD and observed that the formation of gallstones was accompanied by an increase in serum and bile total cholesterol concentrations, while by a decrease in total bile acid concentration in bile. The formation of gallstones was also accompanied by downregulation of hepatic caveolin-3 (CAV3) expression, and downregulation of CAV3 and cholecystokinin A receptor (CCKAR) expression in the gallbladder. Our results suggest that CAV3 and CCKAR may be involved in CGD.
Publish Date 2014-07-26 13:36
Citation Xu GQ, Xu CF, Chen HT, Liu S, Teng XD, Xu GY, Yu CH. Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice. World J Gastroenterol 2014; 20(28): 9513-9518
URL http://www.wjgnet.com/1007-9327/full/v20/i28/9513.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i28.9513
Full Article (PDF) WJG-20-9513.pdf
Full Article (Word) WJG-20-9513.doc
Manuscript File 8927-Review.docx
Answering Reviewers 8927-Answering reviewers.pdf
Copyright License Agreement 8927-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 8927-Language certificate.pdf
Peer-review Report 8927-Peer reviews.pdf
Scientific Editor Work List 8927-Scientific editor work list.doc