Publication Name	World Journal of Gastroenterology
Manuscript ID	8927
Country	China

Received	2014-01-13 10:54
Peer-Review Started	2014-01-23 08:53
To Make the First Decision	2014-02-14 13:51
Return for Revision	2014-02-20 10:29
Revised	2014-03-19 08:52
Second Decision	2014-04-23 09:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-23 10:21
Articles in Press	2014-05-23 09:19
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-14 15:32
Typeset the Manuscript	2014-07-10 09:07
Publish the Manuscript Online	2014-07-26 13:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Guo-Qiang Xu, Cheng-Fu Xu, Hong-Tan Chen, Shan Liu, Xiao-Dong Teng, Gen-Yun Xu and Chao-Hui Yu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81070366
Corresponding Author	Guo-Qiang Xu, MD, Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zyxgq@sina.cn
Key Words	Cholesterol gallstone disease; Caveolin-3; Cholecystokinin A receptor; Lithogenic diet; Mechanism
Core Tip	Cholesterol gallstone disease (CGD) is one of the most common digestive diseases worldwide, while the mechanisms of this disease are not fully understood. In this study, we established a mouse model of CGD and observed that the formation of gallstones was accompanied by an increase in serum and bile total cholesterol concentrations, while by a decrease in total bile acid concentration in bile. The formation of gallstones was also accompanied by downregulation of hepatic caveolin-3 (CAV3) expression, and downregulation of CAV3 and cholecystokinin A receptor (CCKAR) expression in the gallbladder. Our results suggest that CAV3 and CCKAR may be involved in CGD.
Publish Date	2014-07-26 13:36
Citation	Xu GQ, Xu CF, Chen HT, Liu S, Teng XD, Xu GY, Yu CH. Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice. World J Gastroenterol 2014; 20(28): 9513-9518
URL	http://www.wjgnet.com/1007-9327/full/v20/i28/9513.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i28.9513

Full Article (PDF)	WJG-20-9513.pdf
Full Article (Word)	WJG-20-9513.doc
Manuscript File	8927-Review.docx
Answering Reviewers	8927-Answering reviewers.pdf
Copyright License Agreement	8927-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8927-Language certificate.pdf
Peer-review Report	8927-Peer reviews.pdf
Scientific Editor Work List	8927-Scientific editor work list.doc