Publication Name	World Journal of Clinical Cases
Manuscript ID	89322
Country	Bulgaria

Received	2023-10-27 19:44
Peer-Review Started	2023-10-27 19:44
To Make the First Decision
Return for Revision	2023-12-06 06:16
Revised	2023-12-20 22:41
Second Decision	2024-01-19 02:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-01-19 06:22
Articles in Press	2024-01-19 06:22
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-01-25 18:15
Typeset the Manuscript	2024-02-04 01:23
Publish the Manuscript Online	2024-02-20 09:51

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	New strategies in the diagnosis and treatment of immune-checkpoint inhibitor-mediated colitis
Manuscript Source	Invited Manuscript
All Author List	Tsvetelina Velikova, Boris Krastev, Milena Gulinac, Miroslav Zashev, Vasko Graklanov and Milena Peruhova
ORCID	Author(s) ORCID Number Boris Krastev http://orcid.org/0000-0003-4196-0828 Milena Gulinac http://orcid.org/0000-0001-7970-9378 Miroslav Zashev http://orcid.org/0000-0003-3265-1548 Vasko Graklanov http://orcid.org/0000-0002-7059-1411 Milena Peruhova http://orcid.org/0000-0002-6618-2324
Funding Agency and Grant Number	Funding Agency Grant Number European Union-NextGenerationEU, through the National Recovery and Resilience Plan of the Republic of Bulgaria No BG-RRP-2.004-0008
Corresponding Author	Milena Peruhova, MD, Assistant Professor, Chief Physician, Division of Gastroenterology , University Hospital "Heart and Brain", 1 Zdrave Street, Burgas 1000, Bulgaria. mperuhova@gmail.com
Key Words	Immune-checkpoint inhibitors; Immune-checkpoint inhibitor-mediated colitis; Inhibitor-mediated colitis management; Immunotherapy-associated colitis; Checkpoint inhibitor-induced colitis; Gastrointestinal adverse effects; Checkpoint inhibitor toxicity; Inhibitor-mediated colitis therapy
Core Tip	Diagnosing and managing immune-checkpoint inhibitor-mediated colitis (IMC) is essential for optimizing the benefits of cancer immunotherapy. This review underscores the importance of accurate diagnosis, differentiating IMC from other colitis, and tailoring treatment strategies for optimal outcomes. Multidisciplinary approaches, including endoscopy, histopathology, and immune profiling, are crucial in diagnosing IMC. Treatment options range from corticosteroids to immunosuppressants, and a personalized approach is often required. Collaborative efforts between oncologists, gastroenterologists, and pathologists are critical to manage this emerging immune-related adverse event effectively.
Publish Date	2024-02-20 09:51
Citation	Velikova T, Krastev B, Gulinac M, Zashev M, Graklanov V, Peruhova M. New strategies in the diagnosis and treatment of immune-checkpoint inhibitor-mediated colitis. World J Clin Cases 2024; 12(6): 1050-1062
URL	https://www.wjgnet.com/2307-8960/full/v12/i6/1050.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i6.1050

Full Article (PDF)	WJCC-12-1050-with-cover.pdf
Full Article (Word)	WJCC-12-1050.docx
Manuscript File	89322-Review-Filipodia.docx
Answering Reviewers	89322-Answering reviewers.pdf
Audio Core Tip	89322-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	89322-Conflict-of-interest statement.pdf
Copyright License Agreement	89322-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89322-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	89322-Language certificate.pdf
Supplementary Material	89322-Supplementary material.pdf
Peer-review Report	89322-Peer-review(s).pdf
Scientific Misconduct Check	89322-Bing-Chen YL-2.png
Scientific Editor Work List	89322-Scientific editor work list.pdf