Publication Name	World Journal of Clinical Cases
Manuscript ID	89371
Country	China

Received	2023-10-29 15:48
Peer-Review Started	2023-10-29 15:49
To Make the First Decision
Return for Revision	2023-12-15 09:02
Revised	2023-12-26 16:04
Second Decision	2024-03-07 03:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-07 08:05
Articles in Press	2024-03-07 08:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-19 01:28
Publish the Manuscript Online	2024-03-25 08:14

ISSN	2307-8960 (online)
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Category	Surgery
Manuscript Type	Case Report
Article Title	Gradient inflammation in the pancreatic stump after pancreaticoduodenectomy: Two case reports and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Tie-Gong Wang, Liang Tian, Xiao-Ling Zhang, Lei Zhang, Xiu-Lei Zhao and De-Shuai Kong
ORCID	Author(s) ORCID Number Tie-Gong Wang http://orcid.org/0000-0001-6616-5930
Funding Agency and Grant Number
Corresponding Author	Tie-Gong Wang, MD, PhD, Attending Doctor, Department of Surgery, Cangzhou Central Hospital, No. 16 Xinhuaxi, Cangzhou 061000, Hebei Province, China. healthbycliff@gmail.com
Key Words	Pancreaticoduodenectomy; Postoperative pancreatic fistula; Inflammation; Digestive reflux; Case report
Core Tip	Postoperative pancreatic fistula (POPF) is a major complication of pancreaticoduodenectomy. However, the underlying mechanisms remain unclear. Compared to the relatively simple histological structure of the gastrointestinal wall, pancreatic stump is undoubtedly the crucial factor in the occurrence of POPF. This study systemically investigated the pathology in pancreatic stumps and provided insights into the underlying mechanisms of POPF. Gradient inflammation and digestive reflux are present in the pancreatic stumps. As the understanding of the role of inflammation in POPF increases, effectively managing the side effects of inflammation will bring about a significant possibility of terminating POPF.
Publish Date	2024-03-25 08:14
Citation	Wang TG, Tian L, Zhang XL, Zhang L, Zhao XL, Kong DS. Gradient inflammation in the pancreatic stump after pancreaticoduodenectomy: Two case reports and review of literature. World J Clin Cases 2024; 12(9): 1649-1659
URL	https://www.wjgnet.com/2307-8960/full/v12/i9/1649.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i9.1649

Full Article (PDF)	WJCC-12-1649-with-cover.pdf
CARE Checklist–2016	89371-CARE Checklist (2016).pdf
Manuscript File	89371_Auto_Edited-YJP.docx
Answering Reviewers	89371-Answering reviewers.pdf
Audio Core Tip	89371-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	89371-Conflict-of-interest statement.pdf
Copyright License Agreement	89371-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	89371-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	89371-Language certificate.pdf
Peer-review Report	89371-Peer-review(s).pdf
Scientific Misconduct Check	89371-Bing-Wang JJ-2.png
Scientific Editor Work List	89371-Scientific editor work list.pdf
CrossCheck Report	89371-CrossCheck report.pdf