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Articles Published Processes
12/14/2023 9:36:11 AM | Browse: 78 | Download: 75
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Received |
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2023-11-05 00:48 |
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Peer-Review Started |
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2023-11-05 00:50 |
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To Make the First Decision |
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Return for Revision |
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2023-11-23 00:48 |
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Revised |
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2023-11-29 11:08 |
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Second Decision |
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2023-12-06 03:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-12-06 03:37 |
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Articles in Press |
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2023-12-06 03:37 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-12-07 01:13 |
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Publish the Manuscript Online |
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2023-12-14 09:36 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Management |
| Manuscript Type |
Editorial |
| Article Title |
Potential therapeutic targets for the prevention of diabetic nephropathy: Glycyrrhetinic acid
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lu Cai, Michael Horowitz and Md Shahidul Islam |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Lu Cai, MD, PhD, Director, Professor, Pediatric Research Institute, Department of Pediatrics, University of Louisville, 570 S. Preston Street, Baxter I, Rm: 304F, Louisville, KY 40202, United States. lu.cai@louisville.edu |
| Key Words |
Insulin resistance; Diabetic cardiomyopathy; Diabetic nephropathy; Glycyrrhetinic acid; Licorice; Chinese herbal remedy |
| Core Tip |
Uncontrolled hyperglycemia or poorly managed disease increases the propensity for a number of diabetes-related complications targeting major organs including the heart, eyes, and kidney. Although the mechanisms by which diabetes induces cardiovascular diseases include oxidative stress and inflammation, when insulin resistance remains the key to the pathogenesis, as implicated in the two reviews in this issue. This editorial mainly comments on the potential preventive application of glycyrrhetinic acid (or 18β-GA) in relation to diabetic nephropathy (DN). The therapeutic or preventive effects of 18β-GA, as a hydrolytic product of glycyrrhizic acid that is a component of licorice, have been appreciated in other disorders, but have received much less attention in relation to diabetic complications. A study in this issue has identified 18β-GA as a therapeutic for preventing DN and provides evidence to support efficacy in cultured human renal tubule cells in vitro. Although it represents a pilot study, the observations support a new therapeutic approach that warrants further exploration. |
| Publish Date |
2023-12-14 09:36 |
| Citation |
Cai L, Horowitz M, Islam MS. Potential therapeutic targets for the prevention of diabetic nephropathy: Glycyrrhetinic acid. World J Diabetes 2023; 14(12): 1717-1720 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i12/1717.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i12.1717 |
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