Publication Name	World Journal of Cardiology
Manuscript ID	89565
Country	India

Received	2023-11-05 17:30
Peer-Review Started	2023-11-05 17:30
To Make the First Decision
Return for Revision	2023-11-30 07:43
Revised	2023-12-03 14:22
Second Decision	2023-12-11 05:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-12-18 07:57
Articles in Press	2023-12-18 07:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-15 07:18
Publish the Manuscript Online	2024-01-19 03:51

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	Development of pulmonary hypertension remains a major hurdle to corrective surgery in Down syndrome
Manuscript Source	Invited Manuscript
All Author List	Akash Batta and Juniali Hatwal
ORCID	Author(s) ORCID Number Akash Batta http://orcid.org/0000-0002-7606-5826 Juniali Hatwal http://orcid.org/0000-0001-5433-0433
Funding Agency and Grant Number
Corresponding Author	Akash Batta, Doctor, MD, Assistant Professor, Researcher, Department of Cardiology, Dayanand Medical College and Hospital, Tagore Nagar, Civil Lines, Ludhiana 141001, Punjab, India. akashbatta02@gmail.com
Key Words	Down syndrome; Congenital heart disease; Pulmonary hypertension; Cardiac transplantation; Pulmonary vascular resistance; Surgical correction
Core Tip	Down syndrome is the most common chromosomal abnormality with roughly half of them having associated congenital heart disease (CHD). People with Down syndrome are especially predisposed to early development of severe pulmonary hypertension (PH) compared with CHDs in general population. It is not uncommon to come across Down syndrome patients with uncorrected shunts in adulthood with irreversible PH at which stage the only option available is a combined heart-lung transplant. However, despite the guidelines laid by authorities, the rates of cardiac transplant in adults with Down syndrome remain dismal largely attributable to the high prevalence of intellectual disability in them.
Publish Date	2024-01-19 03:51
Citation	Batta A, Hatwal J. Development of pulmonary hypertension remains a major hurdle to corrective surgery in Down syndrome. World J Cardiol 2023; 16(1): 1-4
URL	https://www.wjgnet.com/1949-8462/full/v16/i1/1.htm
DOI	https://dx.doi.org/10.4330/wjc.v16.i1.1

Full Article (PDF)	WJC-16-1-with-cover.pdf
Full Article (Word)	WJC-16-1.docx
Manuscript File	89565_Auto_Edited-LJH-YJP.docx
Answering Reviewers	89565-Answering reviewers.pdf
Audio Core Tip	89565-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	89565-Conflict-of-interest statement.pdf
Copyright License Agreement	89565-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	89565-Language certificate.pdf
Peer-review Report	89565-Peer-review(s).pdf
Scientific Misconduct Check	89565-Bing-Liu JH-2.png
Scientific Misconduct Check	89565-CrossCheck.png
Scientific Editor Work List	89565-Scientific editor work list.pdf
CrossCheck Report	89565-CrossCheck report.pdf