| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Feng Chen, Zhuo-Qing Wu, Hao-Shuang Liu, Su Yan, You-Xiang Wang, Miao Xing, Xiao-Qin Song and Su-Ying Ding |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
72101236 |
| China Postdoctoral Science Foundation |
2022M722900 |
| Collaborative Innovation Project of Zhengzhou City |
XTCX2023006 |
| Nursing Team Project of the First Affiliated Hospital of Zhengzhou University |
HLKY2023005 |
|
| Corresponding Author |
Su-Ying Ding, MD, Director, Director, Doctor, Doctor, Health Management Center, The First Affiliated Hospital of Zhengzhou University, No. 1 Longhu Middle Ring Road, Jinshui District, Zhengzhou 450052, Henan Province, China. fccdingsy@zzu.edu.cn |
| Key Words |
Metabolic dysfunction-associated fatty liver disease; High-normal alanine aminotransferase level; Cumulative effect; Cox proportional hazards regression; Cohort study |
| Core Tip |
Limited evidence exists regarding the association between persistently elevated high-normal alanine transaminase (ALT) levels and the risk of new-onset metabolic dysfunction-associated fatty liver disease (MAFLD). This cohort study analysed 3553 participants followed for four consecutive health examinations between 2017 and 2020 and measured the cumulative effects of excess high-normal ALT (ehALT). Among the participants, the incidence rate of MAFLD showed a linear increasing trend for the cumulative ehALT group. The hazard ratios of new-onset MAFLD were significantly increased in the third and fourth quartiles of the equally and unequally weighted cumulative effects of ehALT. Among Chinese adults, long-term high-normal ALT levels were related to a cumulative increased risk of new-onset MAFLD. |
| Publish Date |
2024-03-14 17:31 |
| Citation |
Chen JF, Wu ZQ, Liu HS, Yan S, Wang YX, Xing M, Song XQ, Ding SY. Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China. World J Gastroenterol 2024; 30(10): 1346-1357 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i10/1346.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i10.1346 |
