Publication Name	World Journal of Gastroenterology
Manuscript ID	8964
Country	Germany

Received	2014-01-14 08:47
Peer-Review Started	2014-01-14 12:08
To Make the First Decision	2014-01-24 11:49
Return for Revision	2014-01-25 17:16
Revised	2014-02-20 21:59
Second Decision	2014-05-29 20:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-29 20:39
Articles in Press	2014-05-29 21:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-07 10:50
Publish the Manuscript Online	2014-08-20 18:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Observational Study
Article Title	Age-related differences in response to peginterferon alfa-2a/ribavirin in patients with chronic hepatitis C infection
Manuscript Source	Unsolicited Manuscript
All Author List	Claudia Roeder, Sabine Jordan, Julian Schulze zur Wiesch, Heike Pfeiffer-Vornkahl, Dietrich Hueppe, Stefan Mauss, Elmar Zehnter, Sabine Stoll, Ulrich Alshuth, Ansgar W Lohse and Stefan Lueth
Funding Agency and Grant Number	Funding Agency Grant Number Deutsche Forschungsgemeinschaft LU B62/2-1 (to zur Wiesch JS) Deutsche Forschungsgemeinschaft SFB841 A6 to zur Wiesch JS Deutsches Zentrum für Infektionsforschung to zur Wiesch JS
Corresponding Author	Dr. Stefan Lueth, PD, Department of Medicine Ⅰ, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. slueth@uke.de
Key Words	hepatitis C virus infection; Older patients; Patients ≥ 60 years; Geriatric; Therapy; Non-interventional study; Epidemiology
Core Tip	There are concerns to initiate treatment in elderly patients because of perceived lower sustained virological response (SVR) rates and serious adverse events. We aimed to evaluate safety and efficacy of pegylated interferon alfa-2a and ribavirin therapy in elderly patients. Patients were stratified according to age (< 60 years vs ≥ 60 years). SVR rates showed an age related difference in patients with genotype 1 (23.7% vs 43.7%, p < 0.001) but not in genotype 2/3 infections (57.7% vs 64.6%, p = 0.341). Elderly hepatitis C virus patients differ in clinical characteristics and treatment outcome from younger patients and demand special attention from their practitioner.
Publish Date	2014-08-20 18:38
Citation	Roeder C, Jordan S, Schulze zur Wiesch J, Pfeiffer-Vornkahl H, Hueppe D, Mauss S, Zehnter E, Stoll S, Alshuth U, Lohse AW, Lueth S. Age-related differences in response to peginterferon alfa-2a/ribavirin in patients with chronic hepatitis C infection. World J Gastroenterol 2014; 20(31): 10984-10993
URL	http://www.wjgnet.com/1007-9327/full/v20/i31/10984.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i31.10984

Full Article (PDF)	WJG-20-10984.pdf
Full Article (Word)	WJG-20-10984.doc
Manuscript File	8964-Review.docx
Answering Reviewers	8964-Answering reviewers.pdf
Copyright License Agreement	8964-Coypright assignment.pdf
Peer-review Report	8964-Peer review(s).pdf
Scientific Misconduct Check	8964-CrossCheck.jpg
Scientific Editor Work List	8964-Scientific editor work list.pdf