Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	89682
Country	South Korea

Received	2023-11-09 05:03
Peer-Review Started	2023-11-09 05:05
To Make the First Decision
Return for Revision	2023-12-08 02:36
Revised	2024-01-03 07:07
Second Decision	2024-02-03 02:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-02-03 05:01
Articles in Press	2024-02-03 05:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-13 07:05
Publish the Manuscript Online	2024-03-22 11:13

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Etanercept-synthesizing adipose-derived stem cell secretome: A promising therapeutic option for inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Say-June Kim, Ok-Hee Kim, Ha-Eun Hong, Ji Hyeon Ju and Do Sang Lee
ORCID	Author(s) ORCID Number Ok-Hee Kim http://orcid.org/0000-0002-9204-2587 Ha-Eun Hong http://orcid.org/0000-0002-4361-4809 Do Sang Lee http://orcid.org/0000-0002-1528-2317
Funding Agency and Grant Number	Funding Agency Grant Number the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) NRF-2021R1F1A1064566
Corresponding Author	Do Sang Lee, MD, PhD, Doctor, Professor, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, South Korea. dosangs@catholic.ac.kr
Key Words	Adipose-derived stem cells; Etanercept; Inflammatory bowel disease; Secretome; Tumor necrosis factor-α
Core Tip	This study explores a promising therapeutic strategy for treating inflammatory bowel disease (IBD) by harnessing the potential of a secretome derived from adipose-derived stem cells (ASCs) engineered to produce etanercept, a tumor necrosis factor-blocking drug. The findings demonstrate that the Etanercept-Secretome (Et-Sec) offers enhanced anti-inflammatory effects compared to traditional etanercept treatment. This superior therapeutic potential of the Et-Sec in IBD is attributed to its unique combination of etanercept synthesis and the intrinsic anti-inflammatory and immunomodulatory properties of ASC secretome, making it a promising candidate for advanced IBD therapy.
Publish Date	2024-03-22 11:13
Citation	Kim SJ, Kim OH, Hong HE, Ju JH, Lee DS. Etanercept-synthesizing adipose-derived stem cell secretome: A promising therapeutic option for inflammatory bowel disease. World J Gastrointest Surg 2024; 16(3): 882-892
URL	https://www.wjgnet.com/1948-9366/full/v16/i3/882.htm
DOI	https://dx.doi.org/10.4240/wjgs.v16.i3.882

Full Article (PDF)	WJGS-16-882-with-cover.pdf
The ARRIVE Guidelines	89682-The ARRIVE guidelines.pdf
Manuscript File	89682_Auto_Edited-YJP.docx
Answering Reviewers	89682-Answering reviewers.pdf
Audio Core Tip	89682-Audio core tip.mp3
Biostatistics Review Certificate	89682-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89682-Conflict-of-interest statement.pdf
Copyright License Agreement	89682-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89682-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	89682-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	89682-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	89682-Language certificate.pdf
Peer-review Report	89682-Peer-review(s).pdf
Scientific Misconduct Check	89682-Bing-Li L-2.png
Scientific Editor Work List	89682-Scientific editor work list.pdf