Publication Name	World Journal of Gastroenterology
Manuscript ID	89742
Country	Singapore

Received	2023-11-11 09:10
Peer-Review Started	2023-11-11 09:12
To Make the First Decision
Return for Revision	2024-01-05 11:00
Revised	2024-01-08 03:03
Second Decision	2024-02-05 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-02-05 05:07
Articles in Press	2024-02-05 05:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-02-26 05:45
Publish the Manuscript Online	2024-03-06 06:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Genetic risk stratification of inflammatory bowel disease-associated venous thromboembolism: An Asian perspective
Manuscript Source	Invited Manuscript
All Author List	James Guoxian Huang
ORCID	Author(s) ORCID Number James Guoxian Huang http://orcid.org/0000-0002-5869-4194
Funding Agency and Grant Number
Corresponding Author	James Guoxian Huang, MBBS, MRCP, Assistant Professor, Doctor, Doctor, Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Khoo Teck Puat-National University Children’s Medical Institute, National University Health System, NUHS Tower Block Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore. paehgj@nus.edu.sg
Key Words	Thromboembolism; Inflammatory bowel disease; Genetic screening; Venous thromboembolism; Thromboprophylaxis
Core Tip	Polygenic scoring models may determine an inflammatory bowel disease patient’s actual risk for venous thromboembolism (VTE) with greater accuracy than monogenic screening alone. This may be due to the cumulative effect of multiple pro-thrombotic genetic loci having a greater influence on thrombotic risk, rather than specific genetic mutations. There needs to be cross-validation of such scoring models in ethnically diverse populations as there is significant heterogeneity in the prevalence of genes implicated in thrombophilia. A composite score combining clinical and polygenic risk factors would further enhance the accuracy in determining one’s VTE risk.
Publish Date	2024-03-06 06:10
Citation	Huang JG. Genetic risk stratification of inflammatory bowel disease-associated venous thromboembolism: An Asian perspective. World J Gastroenterol 2024; 30(9): 1250-1252
URL	https://www.wjgnet.com/1007-9327/full/v30/i9/1250.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i9.1250

Full Article (PDF)	WJG-30-1250-with-cover.pdf
Manuscript File	89742_Auto_Edited-YJP.docx
Answering Reviewers	89742-Answering reviewers.pdf
Audio Core Tip	89742-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	89742-Conflict-of-interest statement.pdf
Copyright License Agreement	89742-Copyright license agreement.pdf
Peer-review Report	89742-Peer-review(s).pdf
Scientific Misconduct Check	89742-Bing-Qu XL-2.jpg
Scientific Editor Work List	89742-Scientific editor work list.pdf
CrossCheck Report	89742-CrossCheck report.pdf