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Articles Published Processes
2/26/2024 1:28:46 PM | Browse: 130 | Download: 320
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Received |
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2023-11-23 19:04 |
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Peer-Review Started |
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2023-11-23 19:05 |
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To Make the First Decision |
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Return for Revision |
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2024-01-05 05:47 |
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Revised |
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2024-01-13 17:10 |
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Second Decision |
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2024-01-30 02:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-01-30 06:54 |
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Articles in Press |
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2024-01-30 06:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-02-05 00:07 |
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Publish the Manuscript Online |
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2024-02-26 13:28 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Editorial |
| Article Title |
Immune signature of small bowel adenocarcinoma and the role of tumor microenvironment
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Grigorios Christodoulidis, Marina Nektaria Kouliou and Konstantinos Eleftherios Koumarelas |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Grigorios Christodoulidis, PhD, Doctor, Doctor, Editor-in-Chief, Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa 41110, Greece. gregsurg09@gmail.com |
| Key Words |
Programmed cell death 1; Programmed cell death-ligand 1; Programmed death ligand; Small bowel adenocarcinoma; Tumor infiltrating lymphocytes; Tumor microenvironment; Microsatellite instability |
| Core Tip |
Small bowel adenocarcinoma (SBA) is an uncommon gastrointestinal tumor, accounting for fewer than 3% of all cases, even though it constitutes 95% of the gastrointestinal tract. SBA, which is mostly located in the duodenum, typically goes undetected for a long period of time, resulting to a late-stage discovery and a dismal prognosis. The immunological response, consisting of CD4+ and CD8+ T-lymphocytes, is critical in determining the prognosis. Programmed cell death 1/programmed cell death-ligand 1 (PD-L1) pathway, which is known to be involved in immune evasion in cancer, is implicated in SBA, with PD-L1 expression to a variety of prognostic consequences. The complicated interaction of immunological components, including as TILs and regulatory T cells, emphasizes the complexities of SBA. |
| Publish Date |
2024-02-26 13:28 |
| Citation |
Christodoulidis G, Kouliou MN, Koumarelas KE. Immune signature of small bowel adenocarcinoma and the role of tumor microenvironment. World J Gastroenterol 2024; 30(8): 794-798 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i8/794.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i8.794 |
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