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Articles Published Processes
3/15/2024 8:06:34 AM | Browse: 99 | Download: 302
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Received |
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2023-11-26 14:51 |
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Peer-Review Started |
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2023-11-26 14:52 |
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To Make the First Decision |
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Return for Revision |
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2023-12-17 02:18 |
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Revised |
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2023-12-22 01:09 |
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Second Decision |
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2023-12-29 02:43 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-12-29 04:55 |
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Articles in Press |
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2023-12-29 04:55 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-03-12 07:34 |
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Publish the Manuscript Online |
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2024-03-15 08:06 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Minireviews |
| Article Title |
Update on the reciprocal interference between immunosuppressive therapy and gut microbiota after kidney transplantation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Maurizio Salvadori and Giuseppina Rosso |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Maurizio Salvadori, MD, Professor, Department of Renal Transplantation, Careggi University Hospital, 18 Viale Pieraccini, Florence 50139, Tuscany, Italy. maurizio.salvadori1@gmail.com |
| Key Words |
Immunosuppressive therapy; Kidney transplantation; Gut microbiota; Dysbiosis; Pathobionts; Graft outcomes |
| Core Tip |
Gut dysbiosis frequently occurs in the first period after kidney transplantation. Among the different causes, immunosuppressive drugs play a relevant role. There is a reciprocal effect between immunosuppressive drugs and the gut microbiota. Indeed, immunosuppressive drugs may change the gut microbiota composition causing dysbiosis as related side effects as rejection and infections. In contrast, the gut microbiota may alter the pharmacokinetic of immunosuppressive drugs determining modification in their metabolism and favoring the presence of substances with lower or higher immunosuppressant effect with respect to the original compound. Physicians should pay particular attention to these possibilities and carefully control both changes in the gut microbiota and the correct level of immunosuppressive drugs. |
| Publish Date |
2024-03-15 08:06 |
| Citation |
Salvadori M, Rosso G. Update on the reciprocal interference between immunosuppressive therapy and gut microbiota after kidney transplantation. World J Transplant 2023; In press |
| URL |
https://www.wjgnet.com/2220-3230/full/v14/i1/90194.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v14.i1.90194 |
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