Publication Name	World Journal of Cardiology
Manuscript ID	90347
Country	Italy

Received	2023-11-30 13:34
Peer-Review Started	2023-11-30 13:34
To Make the First Decision
Return for Revision	2023-12-28 02:14
Revised	2024-01-02 08:17
Second Decision	2024-01-29 02:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-01-29 06:37
Articles in Press	2024-01-29 06:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-02-20 08:33
Publish the Manuscript Online	2024-02-21 02:50

ISSN	1949-8462 (online)
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	Facing ethical concerns in the age of precise gene therapy: Outlook on inherited arrhythmias
Manuscript Source	Invited Manuscript
All Author List	Federico Carbone and Fabrizio Montecucco
ORCID	Author(s) ORCID Number Federico Carbone http://orcid.org/0000-0003-2957-4078 Fabrizio Montecucco http://orcid.org/0000-0003-0823-8729
Funding Agency and Grant Number	Funding Agency Grant Number Italian Ministry of Health 2754291 Internal Medicine Department of the University of Genoa
Corresponding Author	Fabrizio Montecucco, MD, PhD, Full Professor, Department of Internal Medicine and Medical Specialties, University of Genoa, IRCCS Azienda Osped, IST Ist Nazl Ric Cancro, University of San Martino, Clinical of Internal, 6 Viale Benedetto 15, Genoa 16132, Italy. fabrizio.montecucco@unige.it
Key Words	Ethics; Inherited arrhythmias; CRISPR/Cas9; Gene therapy; Equitable accessibility
Core Tip	As for other diseases, inherited arrhythmias may take advantage from gene editing. Even we are still far from clinical translation, ethical issues need to be considered in order to proceed in this research field avoiding any misconduct. Off-target effects, equitable accessibility of life-saving gene therapies and economic burden for healthcare systems are key issues that need to addressed by regulatory entities.
Publish Date	2024-02-21 02:50
Citation	Carbone F, Montecucco F. Facing ethical concerns in the age of precise gene therapy: Outlook on inherited arrhythmias. World J Cardiol 2024; 16(2): 64-66
URL	https://www.wjgnet.com/1949-8462/full/v16/i2/64.htm
DOI	https://dx.doi.org/10.4330/wjc.v16.i2.64

Full Article (PDF)	WJC-16-64-with-cover.pdf
Full Article (Word)	WJC-16-64.docx
Manuscript File	90347_Auto_Edited-LJH-YJP.docx
Answering Reviewers	90347-Answering reviewers.pdf
Audio Core Tip	90347-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	90347-Conflict-of-interest statement.pdf
Copyright License Agreement	90347-Copyright license agreement.pdf
Peer-review Report	90347-Peer-review(s).pdf
Scientific Misconduct Check	90347-Bing-Liu JH-2.png
Scientific Misconduct Check	90347-CrossCheck.png
Scientific Editor Work List	90347-Scientific editor work list.pdf
CrossCheck Report	90347-CrossCheck report.pdf