Publication Name	World Journal of Gastroenterology
Manuscript ID	9039
Country	Brazil

Received	2014-01-17 12:18
Peer-Review Started	2014-01-17 18:42
To Make the First Decision	2014-02-14 14:41
Return for Revision	2014-02-18 11:26
Revised	2014-03-04 03:20
Second Decision	2014-05-05 09:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-05 09:53
Articles in Press	2014-05-23 10:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-14 18:34
Publish the Manuscript Online	2014-08-29 11:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Physiology
Manuscript Type	Randomized Controlled Trial
Article Title	Glutamine prevents oxidative stress in a model of mesenteric ischemia and reperfusion
Manuscript Source	Unsolicited Manuscript
All Author List	Gilmara Pandolfo Zabot, Gustavo Franco Carvalhal, Norma Possa Marroni, Renata Minuzzo Hartmann, Vinícius Duval da Silva and Henrique Sarubbi Fillmann
Funding Agency and Grant Number	Funding Agency Grant Number Pro-bolsas/PUCRS
Corresponding Author	Correspondence to: Gilmara Pandolfo Zabot, Ms Sci, Department of Surgery, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Rua Duque de Caxias, 1012/19, Marechal Rondon, Porto Alegre, RS 90610-000, Brazil. gilmarapandolfo@terra.com.br
Key Words	Ischemia-reperfusion; Glutamine; Lipid peroxidation; Superoxide dismutase; Nuclear factor-kappa beta; Interleukin 6
Core Tip	Ischemia-reperfusion (I/R) leads to oxidative stress, with local and systemic consequences. Many enzymes and interleukins have been implicated in this process, among them interleukin-6 (IL-6) and nuclear factor kappa beta (NF-?B). The exact role of these enzymes is still not clear. Some substances, such as glutamine, have been studied as protective agents against oxidative stress. In an animal experimental model of intestinal I/R we have found that glutamine reduced lipid peroxidation, preserved superoxide dismutase activity, and decreased the expression of IL-6 and NF-?B in both lung and intestine, suggesting a protective role of this amino acid in the setting of intestinal I/R.
Publish Date	2014-08-29 11:57
Citation	Zabot GP, Carvalhal GF, Marroni NP, Hartmann RM, da Silva VD, Fillmann HS. Glutamine prevents oxidative stress in a model of mesenteric ischemia and reperfusion. World J Gastroenterol 2014; 20(32): 11406-11414
URL	http://www.wjgnet.com/1007-9327/full/v20/i32/11406.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i32.11406

Full Article (PDF)	WJG-20-11406.pdf
Full Article (Word)	WJG-20-11406.doc
Manuscript File	9039-Review.doc
Answering Reviewers	9039-Answering reviewers.pdf
Biostatistics Review Certificate	Biostatistician_Review_Report_20140117034200.xls
Copyright License Agreement	9039-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140117034110.pdf
Non-Native Speakers of English Editing Certificate	9039-Language certificate.pdf
Peer-review Report	9039-Peer review(s).pdf
Scientific Editor Work List	9039-Scientific editor work list.pdf