Publication Name	World Journal of Methodology
Manuscript ID	90624
Country	Greece

Received	2023-12-08 22:18
Peer-Review Started	2023-12-08 22:18
To Make the First Decision
Return for Revision	2023-12-22 20:47
Revised	2023-12-23 09:09
Second Decision	2024-01-17 02:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-01-17 08:38
Articles in Press	2024-01-17 08:38
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-01-14 14:29
Typeset the Manuscript	2024-02-28 07:31
Publish the Manuscript Online	2024-03-07 09:32

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Editorial
Article Title	Pivotal role of exosomes in diagnosis and treatment of esophageal cancer in a new era of precision medicine
Manuscript Source	Invited Manuscript
All Author List	Grigorios Christodoulidis, Konstantinos Eleftherios Koumarelas and Marina Nektaria Kouliou
ORCID	Author(s) ORCID Number Grigorios Christodoulidis http://orcid.org/0000-0003-3413-0666 Konstantinos Eleftherios Koumarelas http://orcid.org/0000-0002-5614-4770 Marina Nektaria Kouliou http://orcid.org/0000-0002-2055-2297
Funding Agency and Grant Number
Corresponding Author	Grigorios Christodoulidis, MD, PhD, Surgeon, Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa 41110, Greece. gregsurg@yahoo.gr
Key Words	Exosomes; Esophageal cancer; Diagnostic methods; Novel therapies
Core Tip	Esophageal cancer (EC) is a global health concern ranking seventh in incidence and sixth in mortality worldwide, with over 604000 new cases and 544000 deaths in 2020. Despite advancements in therapies, nearly half of EC patients experience distant metastasis or therapeutic resistance, resulting in a 5-year survival rate below 25%. Traditional screening methods are limited, necessitating the need for non-invasive alternatives. Liquid biopsy, particularly focusing on exosomes, emerges as a promising option for early EC detection. Exosomes, small vesicles for intercellular communication, carry diverse biomarkers and play a crucial role in tumorigenesis. Notably, exosomal microRNAs, long non-coding RNAs, and circular RNAs show potential as diagnostic and prognostic markers for esophageal squamous cell carcinoma. Beyond diagnosis, exosomes serve as effective delivery tools for therapeutic agents, exhibiting advantages in immunotherapy, gene therapy, and drug delivery, presenting a multifaceted approach in the battle against EC.
Publish Date	2024-03-07 09:32
Citation	Christodoulidis G, Koumarelas KE, Kouliou MN. Pivotal role of exosomes in diagnosis and treatment of esophageal cancer in a new era of precision medicine. World J Methodol 2024; 14(1): 90624
URL	https://www.wjgnet.com/2222-0682/full/v14/i1/90624.htm
DOI	https://dx.doi.org/10.5662/wjm.v14.i1.90624

Full Article (PDF)	WJM-14-90624-with-cover.pdf
Manuscript File	90624_Auto_Edited-LJH_WangTQ-JLW.docx
Answering Reviewers	90624-Answering reviewers.pdf
Audio Core Tip	90624-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	90624-Conflict-of-interest statement.pdf
Copyright License Agreement	90624-Copyright license agreement.pdf
Peer-review Report	90624-Peer-review(s).pdf
Scientific Misconduct Check	90624-Bing-Liu JH-2.png
Scientific Misconduct Check	90624-CrossCheck.png
Scientific Editor Work List	90624-Scientific editor work list.pdf