| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Red cell distribution width/platelet ratio estimates the 3-year risk of decompensation in Metabolic Dysfunction-Associated Steatotic Liver Disease-induced cirrhosis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Marcello Dallio, Mario Romeo, Paolo Vaia, Salvatore Auletta, Simone Mammone, Marina Cipullo, Luigi Sapio, Angela Ragone, Marco Niosi, Silvio Naviglio and Alessandro Federico |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Silvio Naviglio, MD, PhD, Full Professor, Department of Precision Medicine, Clinical Biochemistry Division, University of Campania Luigi Vanvitelli, Via L. De Crecchio 7, Naples 80138, Italy. silvio.naviglio@unicampania.it |
| Key Words |
Liver cirrhosis; Red blood cell distribution width; Red blood cell distribution width to platelet ratio; Translational Medicine; Prognostic biomarker |
| Core Tip |
The availability of non-invasive tools predicting the first decompensation event (DE) in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-related compensated advanced chronic liver disease (cACLD) context is still demanded. Red cell distribution width to platelet ratio (RPR) has been shown to predict fibrosis in MASLD. Herein, we demonstrate that: (1) RPR predicts the first DE in MASLD-cACLD; (2) RPR predicts acute decompensation as the first DE in these patients; and (3) Patients presenting baseline Clinically Significant Portal Hypertension and RPR > 0.472 show higher risk of 3-year decompensation occurrence. Overall, RPR predicts time and modalities of DE in MASLD-related-ACLD patients, presenting the potential to be a valuable, easy-to perform, non-invasive clinical index. |
| Publish Date |
2024-02-21 09:11 |
| Citation |
Dallio M, Romeo M, Vaia P, Auletta S, Mammone S, Cipullo M, Sapio L, Ragone A, Niosi M, Naviglio S, Federico A. Red cell distribution width/platelet ratio estimates the 3-year risk of decompensation in Metabolic Dysfunction-Associated Steatotic Liver Disease-induced cirrhosis. World J Gastroenterol 2024; 30(7): 685-704 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i7/685.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i7.685 |
