Publication Name	World Journal of Gastroenterology
Manuscript ID	91559
Country	China

Received	2023-12-30 13:56
Peer-Review Started	2023-12-30 13:56
To Make the First Decision
Return for Revision	2024-01-16 08:09
Revised	2024-02-03 09:55
Second Decision	2024-03-14 02:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-14 04:11
Articles in Press	2024-03-14 04:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-28 01:50
Publish the Manuscript Online	2024-04-03 07:21

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Editorial
Article Title	Cellular strategies to induce immune tolerance after liver transplantation: Clinical perspectives
Manuscript Source	Invited Manuscript
All Author List	Ai-Wei Zhou, Jing Jin and Yuan Liu
ORCID	Author(s) ORCID Number Yuan Liu http://orcid.org/0000-0003-4033-1026
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 82000586 and 82241221 Shanghai Immune Therapy Institute
Corresponding Author	Yuan Liu, MD, Assistant Professor, Department of Liver Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 160 Pujian Road, Shanghai 200127, China. liuyuanbird@163.com
Key Words	Cellular therapy; Induced tolerance; Liver transplantation; Regulatory T cells; Regulatory dendritic cells
Core Tip	Immune tolerance after liver transplantation could significantly reduce the long-term side-effects of immunosuppressants. Compared with operational and spontaneous tolerance, induced tolerance by cellular therapy could reduce immunosuppressant dosage at early stage after transplantation. Regulatory immune cells could suppress the inflammatory response, which are widely explored in preclinical and clinical trials. So far, regulatory CD4+ T cells, mesenchymal stromal cells and regulatory dendritic cells are mostly studied. However, even the safety and tolerability of cellular therapy in transplantation recipients have been validated, the overall efficacy of tolerance induction is unsatisfactory. Detailed exploration is required in the future.
Publish Date	2024-04-03 07:21
Citation	Zhou AW, Jin J, Liu Y. Cellular strategies to induce immune tolerance after liver transplantation: Clinical perspectives. World J Gastroenterol 2024; 30(13): 1791-1800
URL	https://www.wjgnet.com/1007-9327/full/v30/i13/1791.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i13.1791

Full Article (PDF)	WJG-30-1791-with-cover.pdf
Manuscript File	91559_Auto_Edited-YJP.docx
Answering Reviewers	91559-Answering reviewers.pdf
Audio Core Tip	91559-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	91559-Conflict-of-interest statement.pdf
Copyright License Agreement	91559-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91559-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	91559-Language certificate.pdf
Peer-review Report	91559-Peer-review(s).pdf
Scientific Misconduct Check	91559-Bing-Li L-2.png
Scientific Editor Work List	91559-Scientific editor work list.pdf